TY - JOUR
T1 - Increased urinary phosphate excretion in pseudohypoparathyroidism type II with long-term treatment with phosphodiesterase inhibitor
AU - Mano, T.
AU - Uchimura, K.
AU - Hayashi, R.
AU - Kobahashi, T.
AU - Fujiwara, K.
AU - Makino, M.
AU - Kakizawa, H.
AU - Nagata, M.
AU - Nakai, A.
AU - Wada, M.
AU - Nagasaka, Akio
AU - Itoh, M.
PY - 1999
Y1 - 1999
N2 - A 58-year-old woman was diagnosed to have pseudohypoparathyroidism (PHP)type II because of the absence of an increase of urinary phosphate secretion, despite a marked increase in urinary cAMP excretion on the Ellsworth-Howard test. We treated the patient with a cyclic-nucleotide phosphodiesterase inhibitor, theophylline, resulting in increased urinary phosphate and cAMP excretions. Dibutyl cAMP administration induced the increase in the urinary phosphate excretion. In this case, the unresponsiveness of the urinary phosphate secretion to cAMP was recovered by a high dose of cAMP or long-term administration of a phosphodiesterase inhibitor. These data imply that cAMP responsiveness to renal tubular phosphate reabsorption should be more strictly elucidated in the patient with PHP type II.
AB - A 58-year-old woman was diagnosed to have pseudohypoparathyroidism (PHP)type II because of the absence of an increase of urinary phosphate secretion, despite a marked increase in urinary cAMP excretion on the Ellsworth-Howard test. We treated the patient with a cyclic-nucleotide phosphodiesterase inhibitor, theophylline, resulting in increased urinary phosphate and cAMP excretions. Dibutyl cAMP administration induced the increase in the urinary phosphate excretion. In this case, the unresponsiveness of the urinary phosphate secretion to cAMP was recovered by a high dose of cAMP or long-term administration of a phosphodiesterase inhibitor. These data imply that cAMP responsiveness to renal tubular phosphate reabsorption should be more strictly elucidated in the patient with PHP type II.
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U2 - 10.1055/s-2007-978804
DO - 10.1055/s-2007-978804
M3 - Article
C2 - 10598827
AN - SCOPUS:0032751520
SN - 0018-5043
VL - 31
SP - 602
EP - 605
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
IS - 11
ER -