Increasing and decreasing phases of ferritin and hemosiderin iron determined by serum ferritin kinetics

Hiroshi Saito, Hisao Hayashi, Akihiro Tomita, Haruhiko Ohashi, Hideaki Maeda, Tomoki Naoe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial stage, but it was slow later. In contrast, the change of hemosiderin iron was slow in the initial stage, but it became rapid later. These changes of ferritin and hemosiderin iron suggest that the turnover of ferritin iron is preferential to that of hemosiderin iron, and that the initially existed ferritin iron is gradually replaced by the ferritin iron recovered by taking iron from hemosiderin in iron mobilization. The crossing of the increasing curves of ferritin and hemosiderin iron in iron addition indicates a switching of the principal storage iron from ferritin to hemosiderin. The crossing point shifted toward a higher storage iron level in the increase of iron deposition. Iron storing capacity can be increased not only by the transformation of ferritin into hemosiderin, but also by the expansion of cell space as seen by hepatomegaly in hereditary hemochromatosis. The amounts of hemosiderin iron exceeded ferritin iron in all 10 patients with chronic hepatitis C even though they had normal storage iron levels. This suggests it is difficult to store iron in the form of ferritin in chronic hepatitis C.

Original languageEnglish
Pages (from-to)213-223
Number of pages11
JournalNagoya Journal of Medical Science
Volume75
Issue number3-4
Publication statusPublished - 04-09-2013
Externally publishedYes

Fingerprint

Hemosiderin
Ferritins
Iron
Serum
Chronic Hepatitis C

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Saito, Hiroshi ; Hayashi, Hisao ; Tomita, Akihiro ; Ohashi, Haruhiko ; Maeda, Hideaki ; Naoe, Tomoki. / Increasing and decreasing phases of ferritin and hemosiderin iron determined by serum ferritin kinetics. In: Nagoya Journal of Medical Science. 2013 ; Vol. 75, No. 3-4. pp. 213-223.
@article{ca174efb750d4b399a55d9b82cb49834,
title = "Increasing and decreasing phases of ferritin and hemosiderin iron determined by serum ferritin kinetics",
abstract = "We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial stage, but it was slow later. In contrast, the change of hemosiderin iron was slow in the initial stage, but it became rapid later. These changes of ferritin and hemosiderin iron suggest that the turnover of ferritin iron is preferential to that of hemosiderin iron, and that the initially existed ferritin iron is gradually replaced by the ferritin iron recovered by taking iron from hemosiderin in iron mobilization. The crossing of the increasing curves of ferritin and hemosiderin iron in iron addition indicates a switching of the principal storage iron from ferritin to hemosiderin. The crossing point shifted toward a higher storage iron level in the increase of iron deposition. Iron storing capacity can be increased not only by the transformation of ferritin into hemosiderin, but also by the expansion of cell space as seen by hepatomegaly in hereditary hemochromatosis. The amounts of hemosiderin iron exceeded ferritin iron in all 10 patients with chronic hepatitis C even though they had normal storage iron levels. This suggests it is difficult to store iron in the form of ferritin in chronic hepatitis C.",
author = "Hiroshi Saito and Hisao Hayashi and Akihiro Tomita and Haruhiko Ohashi and Hideaki Maeda and Tomoki Naoe",
year = "2013",
month = "9",
day = "4",
language = "English",
volume = "75",
pages = "213--223",
journal = "Nagoya Journal of Medical Science",
issn = "0027-7622",
publisher = "Nagoya University, School of Medicine",
number = "3-4",

}

Increasing and decreasing phases of ferritin and hemosiderin iron determined by serum ferritin kinetics. / Saito, Hiroshi; Hayashi, Hisao; Tomita, Akihiro; Ohashi, Haruhiko; Maeda, Hideaki; Naoe, Tomoki.

In: Nagoya Journal of Medical Science, Vol. 75, No. 3-4, 04.09.2013, p. 213-223.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increasing and decreasing phases of ferritin and hemosiderin iron determined by serum ferritin kinetics

AU - Saito, Hiroshi

AU - Hayashi, Hisao

AU - Tomita, Akihiro

AU - Ohashi, Haruhiko

AU - Maeda, Hideaki

AU - Naoe, Tomoki

PY - 2013/9/4

Y1 - 2013/9/4

N2 - We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial stage, but it was slow later. In contrast, the change of hemosiderin iron was slow in the initial stage, but it became rapid later. These changes of ferritin and hemosiderin iron suggest that the turnover of ferritin iron is preferential to that of hemosiderin iron, and that the initially existed ferritin iron is gradually replaced by the ferritin iron recovered by taking iron from hemosiderin in iron mobilization. The crossing of the increasing curves of ferritin and hemosiderin iron in iron addition indicates a switching of the principal storage iron from ferritin to hemosiderin. The crossing point shifted toward a higher storage iron level in the increase of iron deposition. Iron storing capacity can be increased not only by the transformation of ferritin into hemosiderin, but also by the expansion of cell space as seen by hepatomegaly in hereditary hemochromatosis. The amounts of hemosiderin iron exceeded ferritin iron in all 10 patients with chronic hepatitis C even though they had normal storage iron levels. This suggests it is difficult to store iron in the form of ferritin in chronic hepatitis C.

AB - We attempted to clarify the mechanism of the storage iron metabolism. A new program of serum ferritin kinetics was applied for studying the increasing and decreasing phases of ferritin and hemosiderin iron in iron addition and removal in patients with a normal level of iron stores or iron overload. The change of ferritin iron in response to iron addition and removal was rapid in the initial stage, but it was slow later. In contrast, the change of hemosiderin iron was slow in the initial stage, but it became rapid later. These changes of ferritin and hemosiderin iron suggest that the turnover of ferritin iron is preferential to that of hemosiderin iron, and that the initially existed ferritin iron is gradually replaced by the ferritin iron recovered by taking iron from hemosiderin in iron mobilization. The crossing of the increasing curves of ferritin and hemosiderin iron in iron addition indicates a switching of the principal storage iron from ferritin to hemosiderin. The crossing point shifted toward a higher storage iron level in the increase of iron deposition. Iron storing capacity can be increased not only by the transformation of ferritin into hemosiderin, but also by the expansion of cell space as seen by hepatomegaly in hereditary hemochromatosis. The amounts of hemosiderin iron exceeded ferritin iron in all 10 patients with chronic hepatitis C even though they had normal storage iron levels. This suggests it is difficult to store iron in the form of ferritin in chronic hepatitis C.

UR - http://www.scopus.com/inward/record.url?scp=84883231039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883231039&partnerID=8YFLogxK

M3 - Article

C2 - 24640177

AN - SCOPUS:84883231039

VL - 75

SP - 213

EP - 223

JO - Nagoya Journal of Medical Science

JF - Nagoya Journal of Medical Science

SN - 0027-7622

IS - 3-4

ER -