IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain

Qinglan Guo; Jiachun Su; Christi Lee McElheny; Nicole Stoesser; Yohei Doi; Minggui Wang

doi:10.1128/AAC.00536-17

IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain

Qinglan Guo, Jiachun Su, Christi Lee McElheny, Nicole Stoesser, Yohei Doi, Minggui Wang

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as bla_NDM, bla_KPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.

Original language	English
Article number	e00536-17
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00536-17
Publication status	Published - 07-2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00536-17

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title = "IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain",

abstract = "IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.",

author = "Qinglan Guo and Jiachun Su and McElheny, {Christi Lee} and Nicole Stoesser and Yohei Doi and Minggui Wang",

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language = "English",

volume = "61",

journal = "Antimicrobial agents and chemotherapy",

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T1 - IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain

AU - Guo, Qinglan

AU - Su, Jiachun

AU - McElheny, Christi Lee

AU - Stoesser, Nicole

AU - Doi, Yohei

AU - Wang, Minggui

PY - 2017/7

Y1 - 2017/7

N2 - IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.

AB - IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1. Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes. The diversity of IncX group plasmid backbones and accessory genes and the evolution of hybrid IncX plasmids pose a challenge in detecting and classifying them.

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IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain

Abstract

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