Independent association of liver fat accumulation with insulin resistance

Hiroshi Yatsuya, Takashi Nihashi, Enei Ri, Yo Hotta, Kunihiro Matsushita, Takashi Muramatsu, Rei Otsuka, Masaaki Matsunaga, Kentaro Yamashita, Chaochen Wang, Mayu Uemura, Akiko Harada, Hiroshi Fukatsu, Hideaki Toyoshima, Atsuko Aoyama, Koji Tamakoshi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background To examine the association of intrahepatic fat with homeostasis model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, in Japanese adults, and whether intrahepatic fat is associated with insulin resistance independent of waist circumference and other measures of obesity. Methods Fifty-three individuals aged 37-69 were studied. Spectrum obtained using a 3-T magnetic resonance imager was analysed with LCModel to quantify intrahepatic fat. Blood levels of insulin, glucose and other biochemical markers were obtained after 8 h or more fasting. Percent body fat was estimated by a bioelectrical impedance analyzer. HOMA-IR and intrahepatic fat content were log-transformed in the analysis. Results We found a positive correlation between intrahepatic fat and HOMA-IR, which was independent of the anthropometric measures of obesity. In contrast, significant and positive correlations of body mass index, percent body fat, and waist circumference with HOMA-IR were largely explained by their associations with intrahepatic fat. Intrahepatic fat was positively associated with alanine transaminase and triglycerides even after adjustment for HOMA-IR. Conclusion Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. Hypertriglyceridemia and liver injury may directly occur subsequent to intrahepatic fat accumulation.

Original languageEnglish
JournalObesity Research and Clinical Practice
Volume8
Issue number4
DOIs
Publication statusPublished - 01-01-2014

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Insulin Resistance
Fats
Liver
Homeostasis
Obesity
Waist Circumference
Adipose Tissue
Hypertriglyceridemia
Alanine Transaminase
Electric Impedance
Fasting
Triglycerides
Body Mass Index
Magnetic Resonance Spectroscopy
Biomarkers
Insulin
Glucose
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Yatsuya, Hiroshi ; Nihashi, Takashi ; Ri, Enei ; Hotta, Yo ; Matsushita, Kunihiro ; Muramatsu, Takashi ; Otsuka, Rei ; Matsunaga, Masaaki ; Yamashita, Kentaro ; Wang, Chaochen ; Uemura, Mayu ; Harada, Akiko ; Fukatsu, Hiroshi ; Toyoshima, Hideaki ; Aoyama, Atsuko ; Tamakoshi, Koji. / Independent association of liver fat accumulation with insulin resistance. In: Obesity Research and Clinical Practice. 2014 ; Vol. 8, No. 4.
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abstract = "Background To examine the association of intrahepatic fat with homeostasis model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, in Japanese adults, and whether intrahepatic fat is associated with insulin resistance independent of waist circumference and other measures of obesity. Methods Fifty-three individuals aged 37-69 were studied. Spectrum obtained using a 3-T magnetic resonance imager was analysed with LCModel to quantify intrahepatic fat. Blood levels of insulin, glucose and other biochemical markers were obtained after 8 h or more fasting. Percent body fat was estimated by a bioelectrical impedance analyzer. HOMA-IR and intrahepatic fat content were log-transformed in the analysis. Results We found a positive correlation between intrahepatic fat and HOMA-IR, which was independent of the anthropometric measures of obesity. In contrast, significant and positive correlations of body mass index, percent body fat, and waist circumference with HOMA-IR were largely explained by their associations with intrahepatic fat. Intrahepatic fat was positively associated with alanine transaminase and triglycerides even after adjustment for HOMA-IR. Conclusion Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. Hypertriglyceridemia and liver injury may directly occur subsequent to intrahepatic fat accumulation.",
author = "Hiroshi Yatsuya and Takashi Nihashi and Enei Ri and Yo Hotta and Kunihiro Matsushita and Takashi Muramatsu and Rei Otsuka and Masaaki Matsunaga and Kentaro Yamashita and Chaochen Wang and Mayu Uemura and Akiko Harada and Hiroshi Fukatsu and Hideaki Toyoshima and Atsuko Aoyama and Koji Tamakoshi",
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Yatsuya, H, Nihashi, T, Ri, E, Hotta, Y, Matsushita, K, Muramatsu, T, Otsuka, R, Matsunaga, M, Yamashita, K, Wang, C, Uemura, M, Harada, A, Fukatsu, H, Toyoshima, H, Aoyama, A & Tamakoshi, K 2014, 'Independent association of liver fat accumulation with insulin resistance', Obesity Research and Clinical Practice, vol. 8, no. 4. https://doi.org/10.1016/j.orcp.2013.08.002

Independent association of liver fat accumulation with insulin resistance. / Yatsuya, Hiroshi; Nihashi, Takashi; Ri, Enei; Hotta, Yo; Matsushita, Kunihiro; Muramatsu, Takashi; Otsuka, Rei; Matsunaga, Masaaki; Yamashita, Kentaro; Wang, Chaochen; Uemura, Mayu; Harada, Akiko; Fukatsu, Hiroshi; Toyoshima, Hideaki; Aoyama, Atsuko; Tamakoshi, Koji.

In: Obesity Research and Clinical Practice, Vol. 8, No. 4, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Independent association of liver fat accumulation with insulin resistance

AU - Yatsuya, Hiroshi

AU - Nihashi, Takashi

AU - Ri, Enei

AU - Hotta, Yo

AU - Matsushita, Kunihiro

AU - Muramatsu, Takashi

AU - Otsuka, Rei

AU - Matsunaga, Masaaki

AU - Yamashita, Kentaro

AU - Wang, Chaochen

AU - Uemura, Mayu

AU - Harada, Akiko

AU - Fukatsu, Hiroshi

AU - Toyoshima, Hideaki

AU - Aoyama, Atsuko

AU - Tamakoshi, Koji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background To examine the association of intrahepatic fat with homeostasis model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, in Japanese adults, and whether intrahepatic fat is associated with insulin resistance independent of waist circumference and other measures of obesity. Methods Fifty-three individuals aged 37-69 were studied. Spectrum obtained using a 3-T magnetic resonance imager was analysed with LCModel to quantify intrahepatic fat. Blood levels of insulin, glucose and other biochemical markers were obtained after 8 h or more fasting. Percent body fat was estimated by a bioelectrical impedance analyzer. HOMA-IR and intrahepatic fat content were log-transformed in the analysis. Results We found a positive correlation between intrahepatic fat and HOMA-IR, which was independent of the anthropometric measures of obesity. In contrast, significant and positive correlations of body mass index, percent body fat, and waist circumference with HOMA-IR were largely explained by their associations with intrahepatic fat. Intrahepatic fat was positively associated with alanine transaminase and triglycerides even after adjustment for HOMA-IR. Conclusion Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. Hypertriglyceridemia and liver injury may directly occur subsequent to intrahepatic fat accumulation.

AB - Background To examine the association of intrahepatic fat with homeostasis model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, in Japanese adults, and whether intrahepatic fat is associated with insulin resistance independent of waist circumference and other measures of obesity. Methods Fifty-three individuals aged 37-69 were studied. Spectrum obtained using a 3-T magnetic resonance imager was analysed with LCModel to quantify intrahepatic fat. Blood levels of insulin, glucose and other biochemical markers were obtained after 8 h or more fasting. Percent body fat was estimated by a bioelectrical impedance analyzer. HOMA-IR and intrahepatic fat content were log-transformed in the analysis. Results We found a positive correlation between intrahepatic fat and HOMA-IR, which was independent of the anthropometric measures of obesity. In contrast, significant and positive correlations of body mass index, percent body fat, and waist circumference with HOMA-IR were largely explained by their associations with intrahepatic fat. Intrahepatic fat was positively associated with alanine transaminase and triglycerides even after adjustment for HOMA-IR. Conclusion Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. Hypertriglyceridemia and liver injury may directly occur subsequent to intrahepatic fat accumulation.

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U2 - 10.1016/j.orcp.2013.08.002

DO - 10.1016/j.orcp.2013.08.002

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