Independent association of liver fat accumulation with insulin resistance

Hiroshi Yatsuya, Takashi Nihashi, Yuanying Li, Yo Hotta, Kunihiro Matsushita, Takashi Muramatsu, Rei Otsuka, Masaaki Matsunaga, Kentaro Yamashita, Chaochen Wang, Mayu Uemura, Akiko Harada, Hiroshi Fukatsu, Hideaki Toyoshima, Atsuko Aoyama, Koji Tamakoshi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background To examine the association of intrahepatic fat with homeostasis model assessment-insulin resistance (HOMA-IR), a marker of insulin resistance, in Japanese adults, and whether intrahepatic fat is associated with insulin resistance independent of waist circumference and other measures of obesity. Methods Fifty-three individuals aged 37-69 were studied. Spectrum obtained using a 3-T magnetic resonance imager was analysed with LCModel to quantify intrahepatic fat. Blood levels of insulin, glucose and other biochemical markers were obtained after 8 h or more fasting. Percent body fat was estimated by a bioelectrical impedance analyzer. HOMA-IR and intrahepatic fat content were log-transformed in the analysis. Results We found a positive correlation between intrahepatic fat and HOMA-IR, which was independent of the anthropometric measures of obesity. In contrast, significant and positive correlations of body mass index, percent body fat, and waist circumference with HOMA-IR were largely explained by their associations with intrahepatic fat. Intrahepatic fat was positively associated with alanine transaminase and triglycerides even after adjustment for HOMA-IR. Conclusion Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. Hypertriglyceridemia and liver injury may directly occur subsequent to intrahepatic fat accumulation.

Original languageEnglish
Pages (from-to)e350-e355
JournalObesity Research and Clinical Practice
Issue number4
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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