Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono, Katsushi Tokunaga, Yoshiro Saito, Hiromi Sawai, Hiroko Miyadera, Emiko Sugiyama, Keiko Maekawa, Ryosuke Nakamura, Masaki Nagato, Michiko Aihara, Kayoko Matsunaga, Yukitoshi Takahashi, Hirokazu Furuya, Masaaki Muramatsu, Zenrou Ikezawa, Shigeru Kinoshita

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47 Citations (Scopus)

Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs (NSAIDs) and multi-ingredient cold medications are reported to be important inciting drugs. We used two sample sets of Japanese patients to investigate the association between HLA genotypes and cold medicine-related SJS/TEN (CM-SJS/TEN), including acetaminophen-related SJS/TEN (AR-SJS/TEN) with severe mucosal involvement such as severe ocular surface complications (SOC). HLA-A*02:06 was strongly associated with CM-SJS/TEN with SOC and AR-SJS/TEN with SOC. HLA-B*44:03 was also detected as an independent risk allele for CM-, including AR-SJS/TEN with SOC. Analyses using data obtained from CM-SJS/TEN patients without SOC and patients with CM-unrelated SJS/TEN with SOC suggested that these two susceptibility alleles are involved in the development of only CM-SJS/TEN with SOC patients.

Original languageEnglish
Article number4862
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 30-04-2014

All Science Journal Classification (ASJC) codes

  • General

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