TY - JOUR
T1 - Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea
AU - Yamamoto, Masami
AU - Furihata, Chie
AU - Ogiu, Toshiaki
AU - Tsukamoto, Tetsuya
AU - Inada, K. I.
AU - Hirano, Kazuyuki
AU - Tatematsu, Masae
N1 - Funding Information:
This study was supported in part by Grants-in-Aid from CREST (Core Research for Evolutional Science and Technology) of the Japan Science and Technology Corporation, by Grants-in-Aid for Cancer Research from the Ministry of Education, Science, Sports, Culture and Technology, Japan, by the Ministry of Health, Labour and Welfare of Japan, and by a Grant-in-Aid from the Ministry of Health, Labour and Welfare for a Comprehensive 10 Year Strategy for Cancer Control, Japan. We also thank Ms Michiyo Tominaga and Ms Naoko Ban for expert technical assistance.
PY - 2002/5/28
Y1 - 2002/5/28
N2 - Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6±9.9%) in the BALB and lowest in the ICR (12.3±5.7%) mice (P<0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P<0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells. Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors. In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains.
AB - Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6±9.9%) in the BALB and lowest in the ICR (12.3±5.7%) mice (P<0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P<0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells. Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors. In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains.
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U2 - 10.1016/S0304-3835(02)00013-7
DO - 10.1016/S0304-3835(02)00013-7
M3 - Article
C2 - 11888666
AN - SCOPUS:0037188430
SN - 0304-3835
VL - 179
SP - 121
EP - 132
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -
