TY - JOUR
T1 - Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer
T2 - A nested case-control study
AU - Yatsuya, H.
AU - Toyoshima, H.
AU - Tamakoshi, A.
AU - Kikuchi, S.
AU - Tamakoshi, K.
AU - Kondo, T.
AU - Mizoue, T.
AU - Tokui, N.
AU - Hoshiyama, Y.
AU - Sakata, K.
AU - Hayakawa, N.
AU - Yoshimura, T.
N1 - Funding Information:
We sincerely thank all the members of the local health centres and the participants from the cities, towns, and villages for their cooperation in this study. We also thank Dr K Aoki, Professor Emeritus, Nagoya University School of Medicine and the former chairman of the steering committee of the JACC study, and Dr H Sugano, former Director, National Cancer Institute, Tokyo, who greatly contributed to the initiation of the JACC study. The grant sponsor for this paper was the Ministry of Education, Science, Sports and Culture of Japan: 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 12218237.
PY - 2004/8/31
Y1 - 2004/8/31
N2 - We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.
AB - We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.
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U2 - 10.1038/sj.bjc.6602067
DO - 10.1038/sj.bjc.6602067
M3 - Article
C2 - 15280918
AN - SCOPUS:4644221336
SN - 0007-0920
VL - 91
SP - 929
EP - 934
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 5
ER -
