Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: A nested case-control study

Hiroshi Yatsuya, H. Toyoshima, A. Tamakoshi, S. Kikuchi, K. Tamakoshi, T. Kondo, T. Mizoue, N. Tokui, Y. Hoshiyama, K. Sakata, N. Hayakawa, T. Yoshimura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

Original languageEnglish
Pages (from-to)929-934
Number of pages6
JournalBritish Journal of Cancer
Volume91
Issue number5
DOIs
Publication statusPublished - 31-08-2004

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Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Case-Control Studies
Joints
Confounding Factors (Epidemiology)
Disease Susceptibility
Japan
Cohort Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yatsuya, Hiroshi ; Toyoshima, H. ; Tamakoshi, A. ; Kikuchi, S. ; Tamakoshi, K. ; Kondo, T. ; Mizoue, T. ; Tokui, N. ; Hoshiyama, Y. ; Sakata, K. ; Hayakawa, N. ; Yoshimura, T. / Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer : A nested case-control study. In: British Journal of Cancer. 2004 ; Vol. 91, No. 5. pp. 929-934.
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Yatsuya, H, Toyoshima, H, Tamakoshi, A, Kikuchi, S, Tamakoshi, K, Kondo, T, Mizoue, T, Tokui, N, Hoshiyama, Y, Sakata, K, Hayakawa, N & Yoshimura, T 2004, 'Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: A nested case-control study', British Journal of Cancer, vol. 91, no. 5, pp. 929-934. https://doi.org/10.1038/sj.bjc.6602067

Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer : A nested case-control study. / Yatsuya, Hiroshi; Toyoshima, H.; Tamakoshi, A.; Kikuchi, S.; Tamakoshi, K.; Kondo, T.; Mizoue, T.; Tokui, N.; Hoshiyama, Y.; Sakata, K.; Hayakawa, N.; Yoshimura, T.

In: British Journal of Cancer, Vol. 91, No. 5, 31.08.2004, p. 929-934.

Research output: Contribution to journalArticle

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T2 - A nested case-control study

AU - Yatsuya, Hiroshi

AU - Toyoshima, H.

AU - Tamakoshi, A.

AU - Kikuchi, S.

AU - Tamakoshi, K.

AU - Kondo, T.

AU - Mizoue, T.

AU - Tokui, N.

AU - Hoshiyama, Y.

AU - Sakata, K.

AU - Hayakawa, N.

AU - Yoshimura, T.

PY - 2004/8/31

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