Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity

Masato Hoshi, Hiroyasu Ito, Hidetsugu Fujigaki, Masao Takemura, Takeshi Takahashi, Eiichi Tomita, Masami Ohyama, Ryo Tanaka, Kuniaki Saito, Mitsuru Seishima

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1). Indoleamine 2,3-dioxygenase (IDO), the l-tryptophan (l-TRP)-degrading enzyme, plays a key role in the powerful immunomodulatory effects of several different types of immune cells. In this study, we investigated the IDO expression in ATLL cells and the effect of chemotherapy on IDO-initiating l-TRP catabolism in patients with ATLL. Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects. On the other hand, l-TRP level was significantly decreased in ATLL patients compared to that in healthy subjects. In the immunohistochemical staining, IDO was strongly expressed in cytoplasm of ATLL cells. Interestingly, serum l-KYN as well as soluble IL-2 receptor concentrations was significantly reduced, and l-TRP concentrations were significantly increased after chemotherapy. These data provide evidence that IDO is highly expressed in ATLL cells, and that IDO-initiating l-TRP catabolism changes with chemotherapy.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalLeukemia Research
Volume33
Issue number1
DOIs
Publication statusPublished - 01-01-2009
Externally publishedYes

Fingerprint

Indoleamine-Pyrrole 2,3,-Dioxygenase
Adult T Cell Leukemia Lymphoma
Tryptophan
Drug Therapy
Kynurenine
Serum
Human T-lymphotropic virus 1
Interleukin-2 Receptors
Healthy Volunteers
Cytoplasm
Staining and Labeling
T-Lymphocytes
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Hoshi, Masato ; Ito, Hiroyasu ; Fujigaki, Hidetsugu ; Takemura, Masao ; Takahashi, Takeshi ; Tomita, Eiichi ; Ohyama, Masami ; Tanaka, Ryo ; Saito, Kuniaki ; Seishima, Mitsuru. / Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity. In: Leukemia Research. 2009 ; Vol. 33, No. 1. pp. 39-45.
@article{888f5b25c74e4167ace565f5b31f2101,
title = "Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity",
abstract = "Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1). Indoleamine 2,3-dioxygenase (IDO), the l-tryptophan (l-TRP)-degrading enzyme, plays a key role in the powerful immunomodulatory effects of several different types of immune cells. In this study, we investigated the IDO expression in ATLL cells and the effect of chemotherapy on IDO-initiating l-TRP catabolism in patients with ATLL. Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects. On the other hand, l-TRP level was significantly decreased in ATLL patients compared to that in healthy subjects. In the immunohistochemical staining, IDO was strongly expressed in cytoplasm of ATLL cells. Interestingly, serum l-KYN as well as soluble IL-2 receptor concentrations was significantly reduced, and l-TRP concentrations were significantly increased after chemotherapy. These data provide evidence that IDO is highly expressed in ATLL cells, and that IDO-initiating l-TRP catabolism changes with chemotherapy.",
author = "Masato Hoshi and Hiroyasu Ito and Hidetsugu Fujigaki and Masao Takemura and Takeshi Takahashi and Eiichi Tomita and Masami Ohyama and Ryo Tanaka and Kuniaki Saito and Mitsuru Seishima",
year = "2009",
month = "1",
day = "1",
doi = "10.1016/j.leukres.2008.05.023",
language = "English",
volume = "33",
pages = "39--45",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "1",

}

Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity. / Hoshi, Masato; Ito, Hiroyasu; Fujigaki, Hidetsugu; Takemura, Masao; Takahashi, Takeshi; Tomita, Eiichi; Ohyama, Masami; Tanaka, Ryo; Saito, Kuniaki; Seishima, Mitsuru.

In: Leukemia Research, Vol. 33, No. 1, 01.01.2009, p. 39-45.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity

AU - Hoshi, Masato

AU - Ito, Hiroyasu

AU - Fujigaki, Hidetsugu

AU - Takemura, Masao

AU - Takahashi, Takeshi

AU - Tomita, Eiichi

AU - Ohyama, Masami

AU - Tanaka, Ryo

AU - Saito, Kuniaki

AU - Seishima, Mitsuru

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1). Indoleamine 2,3-dioxygenase (IDO), the l-tryptophan (l-TRP)-degrading enzyme, plays a key role in the powerful immunomodulatory effects of several different types of immune cells. In this study, we investigated the IDO expression in ATLL cells and the effect of chemotherapy on IDO-initiating l-TRP catabolism in patients with ATLL. Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects. On the other hand, l-TRP level was significantly decreased in ATLL patients compared to that in healthy subjects. In the immunohistochemical staining, IDO was strongly expressed in cytoplasm of ATLL cells. Interestingly, serum l-KYN as well as soluble IL-2 receptor concentrations was significantly reduced, and l-TRP concentrations were significantly increased after chemotherapy. These data provide evidence that IDO is highly expressed in ATLL cells, and that IDO-initiating l-TRP catabolism changes with chemotherapy.

AB - Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1). Indoleamine 2,3-dioxygenase (IDO), the l-tryptophan (l-TRP)-degrading enzyme, plays a key role in the powerful immunomodulatory effects of several different types of immune cells. In this study, we investigated the IDO expression in ATLL cells and the effect of chemotherapy on IDO-initiating l-TRP catabolism in patients with ATLL. Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects. On the other hand, l-TRP level was significantly decreased in ATLL patients compared to that in healthy subjects. In the immunohistochemical staining, IDO was strongly expressed in cytoplasm of ATLL cells. Interestingly, serum l-KYN as well as soluble IL-2 receptor concentrations was significantly reduced, and l-TRP concentrations were significantly increased after chemotherapy. These data provide evidence that IDO is highly expressed in ATLL cells, and that IDO-initiating l-TRP catabolism changes with chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=55049112968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55049112968&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2008.05.023

DO - 10.1016/j.leukres.2008.05.023

M3 - Article

C2 - 18639341

AN - SCOPUS:55049112968

VL - 33

SP - 39

EP - 45

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 1

ER -