Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model

Mingming Zhao, Atsutoshi Tazumi, Satoru Takayama, Nana Takenaka-Ninagawa, Minas Nalbandian, Miki Nagai, Yumi Nakamura, Masanori Nakasa, Akira Watanabe, Makoto Ikeya, Akitsu Hotta, Yuta Ito, Takahiko Sato, Hidetoshi Sakurai

Research output: Contribution to journalArticlepeer-review

Abstract

Zhao et al. demonstrate that skeletal muscle progenitors and fetal muscle stem cells are time-dependently generated from hiPSCs in early and later stages of differentiation. The fetal muscle stem cells show better muscle regeneration potential and muscle function recovery in a mouse model of muscular dystrophy.

Original languageEnglish
Pages (from-to)80-94
Number of pages15
JournalStem Cell Reports
Volume15
Issue number1
DOIs
Publication statusPublished - 14-07-2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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