Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation

Akira Hokama, Emiko Mizoguchi, Ken Sugimoto, Yasuyo Shimomura, Yosuke Tanaka, Masaru Yoshida, Svend T. Rietdijk, Ype P. De Jong, Scott B. Snapper, Cox Terhorst, Richard S. Blumberg, Atsushi Mizoguchi

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Inflammatory bowel disease is an immune-mediated intestinal inflammatory condition that is associated with an increase in autoantibodies that bind to epithelial cells. However, it is unknown whether the epithelial cell-derived products that are recognized by such autoantibodies are involved in the pathogenic process. Through a combined antigen-screening approach utilizing humoral and cellular immune responses, we identify herein an epithelial lectin, galectin-4, that specifically stimulates IL-6 production by CD4 + T cells. Interestingly, the reactivity of CD4 + T cells to galectin-4 is precisely elicited under intestinal inflammatory conditions. The galectin-4-mediated production of IL-6 is MHC class II independent and induced by PKCθ-associated pathway through the immunological synapse. The galectin-4-mediated stimulation of CD4 + T cells is shown to exacerbate chronic colitis and delay the recovery from acute intestinal injury. These studies identify the presence of an immunogenic, endogenous lectin in the intestine and dissect the biological role of lectin/CD4 + T cell interactions under inflammatory conditions.

Original languageEnglish
Pages (from-to)681-693
Number of pages13
JournalImmunity
Volume20
Issue number6
DOIs
Publication statusPublished - 01-06-2004
Externally publishedYes

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Galectin 4
Lectins
Epithelial Cells
Inflammation
T-Lymphocytes
Autoantibodies
Interleukin-6
Immunological Synapses
Colitis
Humoral Immunity
Inflammatory Bowel Diseases
Cellular Immunity
Cell Communication
Intestines
Antigens
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Hokama, Akira ; Mizoguchi, Emiko ; Sugimoto, Ken ; Shimomura, Yasuyo ; Tanaka, Yosuke ; Yoshida, Masaru ; Rietdijk, Svend T. ; De Jong, Ype P. ; Snapper, Scott B. ; Terhorst, Cox ; Blumberg, Richard S. ; Mizoguchi, Atsushi. / Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation In: Immunity. 2004 ; Vol. 20, No. 6. pp. 681-693.
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Hokama, A, Mizoguchi, E, Sugimoto, K, Shimomura, Y, Tanaka, Y, Yoshida, M, Rietdijk, ST, De Jong, YP, Snapper, SB, Terhorst, C, Blumberg, RS & Mizoguchi, A 2004, ' Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation ', Immunity, vol. 20, no. 6, pp. 681-693. https://doi.org/10.1016/j.immuni.2004.05.009

Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation . / Hokama, Akira; Mizoguchi, Emiko; Sugimoto, Ken; Shimomura, Yasuyo; Tanaka, Yosuke; Yoshida, Masaru; Rietdijk, Svend T.; De Jong, Ype P.; Snapper, Scott B.; Terhorst, Cox; Blumberg, Richard S.; Mizoguchi, Atsushi.

In: Immunity, Vol. 20, No. 6, 01.06.2004, p. 681-693.

Research output: Contribution to journalArticle

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AU - Mizoguchi, Emiko

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AU - Shimomura, Yasuyo

AU - Tanaka, Yosuke

AU - Yoshida, Masaru

AU - Rietdijk, Svend T.

AU - De Jong, Ype P.

AU - Snapper, Scott B.

AU - Terhorst, Cox

AU - Blumberg, Richard S.

AU - Mizoguchi, Atsushi

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