TY - JOUR
T1 - Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion
AU - Ohtsuki, Toshiho
AU - Matsumoto, Masayasu
AU - Kitagawa, Kazuo
AU - Taguchi, Akihiko
AU - Maeda, Yusuke
AU - Hata, Ryuji
AU - Ogawa, Satoshi
AU - Ueda, Hirokazu
AU - Handa, Nobuo
AU - Kamada, Takenobu
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/6/18
Y1 - 1993/6/18
N2 - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.
AB - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.
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U2 - 10.1016/0006-8993(93)91045-T
DO - 10.1016/0006-8993(93)91045-T
M3 - Article
C2 - 8348318
AN - SCOPUS:0027336614
VL - 614
SP - 279
EP - 284
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -