Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Toshiho Ohtsuki, Masayasu Matsumoto, Kazuo Kitagawa, Akihiko Taguchi, Yusuke Maeda, Ryuji Hata, Satoshi Ogawa, Hirokazu Ueda, Nobuo Handa, Takenobu Kamada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBrain Research
Volume614
Issue number1-2
DOIs
Publication statusPublished - 18-06-1993

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Gerbillinae
Brain Ischemia
Ischemia
Neurons
HSP72 Heat-Shock Proteins
Neuroprotective Agents
Prosencephalon
Carotid Arteries
Ligation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Ohtsuki, Toshiho ; Matsumoto, Masayasu ; Kitagawa, Kazuo ; Taguchi, Akihiko ; Maeda, Yusuke ; Hata, Ryuji ; Ogawa, Satoshi ; Ueda, Hirokazu ; Handa, Nobuo ; Kamada, Takenobu. / Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. In: Brain Research. 1993 ; Vol. 614, No. 1-2. pp. 279-284.
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Ohtsuki, T, Matsumoto, M, Kitagawa, K, Taguchi, A, Maeda, Y, Hata, R, Ogawa, S, Ueda, H, Handa, N & Kamada, T 1993, 'Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion', Brain Research, vol. 614, no. 1-2, pp. 279-284. https://doi.org/10.1016/0006-8993(93)91045-T

Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. / Ohtsuki, Toshiho; Matsumoto, Masayasu; Kitagawa, Kazuo; Taguchi, Akihiko; Maeda, Yusuke; Hata, Ryuji; Ogawa, Satoshi; Ueda, Hirokazu; Handa, Nobuo; Kamada, Takenobu.

In: Brain Research, Vol. 614, No. 1-2, 18.06.1993, p. 279-284.

Research output: Contribution to journalArticle

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T1 - Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

AU - Ohtsuki, Toshiho

AU - Matsumoto, Masayasu

AU - Kitagawa, Kazuo

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AU - Maeda, Yusuke

AU - Hata, Ryuji

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AU - Ueda, Hirokazu

AU - Handa, Nobuo

AU - Kamada, Takenobu

PY - 1993/6/18

Y1 - 1993/6/18

N2 - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

AB - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

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