Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Toshiho Ohtsuki, Masayasu Matsumoto, Kazuo Kitagawa, Akihiko Taguchi, Yusuke Maeda, Ryuji Hata, Satoshi Ogawa, Hirokazu Ueda, Nobuo Handa, Takenobu Kamada

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21 Citations (Scopus)

Abstract

Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBrain Research
Volume614
Issue number1-2
DOIs
Publication statusPublished - 18-06-1993

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Ohtsuki, T., Matsumoto, M., Kitagawa, K., Taguchi, A., Maeda, Y., Hata, R., Ogawa, S., Ueda, H., Handa, N., & Kamada, T. (1993). Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. Brain Research, 614(1-2), 279-284. https://doi.org/10.1016/0006-8993(93)91045-T