Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Toshiho Ohtsuki; Masayasu Matsumoto; Kazuo Kitagawa; Akihiko Taguchi; Yusuke Maeda; Ryuji Hata; Satoshi Ogawa; Hirokazu Ueda; Nobuo Handa; Takenobu Kamada

doi:10.1016/0006-8993(93)91045-T

Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Toshiho Ohtsuki, Masayasu Matsumoto, Kazuo Kitagawa, Akihiko Taguchi, Yusuke Maeda, Ryuji Hata, Satoshi Ogawa, Hirokazu Ueda, Nobuo Handa, Takenobu Kamada

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

Original language	English
Pages (from-to)	279-284
Number of pages	6
Journal	Brain Research
Volume	614
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)91045-T
Publication status	Published - 18-06-1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion",

abstract = "Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.",

author = "Toshiho Ohtsuki and Masayasu Matsumoto and Kazuo Kitagawa and Akihiko Taguchi and Yusuke Maeda and Ryuji Hata and Satoshi Ogawa and Hirokazu Ueda and Nobuo Handa and Takenobu Kamada",

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Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion. / Ohtsuki, Toshiho; Matsumoto, Masayasu; Kitagawa, Kazuo; Taguchi, Akihiko; Maeda, Yusuke; Hata, Ryuji; Ogawa, Satoshi; Ueda, Hirokazu; Handa, Nobuo; Kamada, Takenobu.

In: Brain Research, Vol. 614, No. 1-2, 18.06.1993, p. 279-284.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

AU - Ohtsuki, Toshiho

AU - Matsumoto, Masayasu

AU - Kitagawa, Kazuo

AU - Taguchi, Akihiko

AU - Maeda, Yusuke

AU - Hata, Ryuji

AU - Ogawa, Satoshi

AU - Ueda, Hirokazu

AU - Handa, Nobuo

AU - Kamada, Takenobu

PY - 1993/6/18

Y1 - 1993/6/18

N2 - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

AB - Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.

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Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion

Abstract

All Science Journal Classification (ASJC) codes

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