Inducing effects of chronic administration of isoproterenol on 1-acyl-sn-glycero-3-phosphate and 1-acyl-sn -glycero-3-phosphocholine acyltransferases in rat parotid salivary gland

Yashiro Koji, Kameyama Yasunaga, Mizuno Masako, Yokota Yutaka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

1. 1. In rat parotid gland, chronic administration of isoproterenol caused significant increase of linoleic acid and decrease of arachidonic acid at the sn-2 position of phosphatidylcholine. 2. 2. The activities of 1-acyl-sn-glycero-3-phosphate and 1-acyl-sn-glycero-3-phosphocholine acyl-transferases were increased 3-8-fold and 2-fold, respectively, in the parotid gland microsomes of isoproterenol-treated rat. 3. 3. Furthermore, the specificity of these two enzymes for various acyl-CoAs was also changed by administration of isoproterenol. 4. 4. The alteration of unsaturated fatty acid composition at the sn-2 position of phosphatidylcholine was at least in part due to the change of activity and substrate specificity of lysophospholipid acyltransferases.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume90
Issue number2
DOIs
Publication statusPublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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