Infection of hepatitis A virus in Japanese haemophiliacs

K. Hayashi, Y. Fukuda, I. Nakano, Y. Katano, K. Nagano, S. Yokozaki, T. Hayakawa, H. Toyoda, J. Takamatsu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objectives: Outbreaks of hepatitis A virus (HAV) infection in haemophiliacs have been reported from many countries. The aim of this study was to determine the prevalence of hepatitis A virus antibody (HAVAb) in Japanese haemophiliacs. Methods: Sixty-seven male haemophiliacs were recruited for this study of HAV infection. We also compared the rate of HAV infection with that of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis G virus (HGV). Results: Fifteen of 67 haemophiliacs (22.4%) were positive for HAVAb. Prevalence of HAVAb was significantly higher in haemophiliacs than in Japanese normal subjects previously reported (P=0.0001). Age, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and prevalence of HIV, HCV, and HGV were not statistically different between HAVAb positive and HAVAb negative haemophiliacs. We suggest that the use of clotting factor concentrates is closely associated with HAV infection, but HAV infection does not have an effect on clinical course. Conclusions: Administration of clotting factor concentrates may increase risk of HAV infection in haemophiliacs.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalJournal of Infection
Volume42
Issue number1
DOIs
Publication statusPublished - 01-01-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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