Infection with TT virus, a novel transfusion-transmissible DNA virus, in haemophiliacs and in blood products

Shoichi Yokozaki, Hidenori Toyoda, Isao Nakano, Yoshiaki Katano, Mieko Ebata, Yoshihide Fukuda, Junki Takamatsu, Hidehiko Satto, Tetsuo Hayakawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We evaluated the characteristics and rate of infection with TT virus (TTV), a novel DNA virus, in Japanese haemophiliacs. TTV DNA was measured in 60 haemophiliacs by semi-nested polymerase chain reaction. Co-infection with hepatitis C virus (HCV), hepatitis G virus (HGV) and human immunodeficiency virus (HIV) was also evaluated. In addition, the rate of detection of TTV DNA in blood products was evaluated. TTV DNA was detected in 35/60 haemophiliacs (58.3%). There were no differences in the backgrounds or characteristics between haemophiliacs with and without TTV infection, except for higher levels of IgG and IgM in patients with TTV infection. In patients infected with TTV of types other than type 1, which are rarely detected in Japan, the rate of co-infection with HCV of imported types was high: TTV of types other than type 1 in Japanese haemophiliacs were probably transmitted by imported blood products. TTV DNA was detected in over half of the blood products tested, but TTV DNA concentrations in these products were lower than in the serum of haemophiliacs.

Original languageEnglish
Pages (from-to)1114-1119
Number of pages6
JournalBritish Journal of Haematology
Volume105
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology

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