Infections with organisms producing extended-spectrum β-lactamase

David L. Paterson, Yohei Doi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Extended-spectrum β-lactamases (ESBL) are enzymes produced by a variety of Gram-negative bacilli, which confer reduced susceptibility to third-generation cephalosporins and aztreonam. Resistance to other antibiotic classes (such as aminoglycosides or fluoroquinolones) is also frequently observed in ESBL-producing organisms. Outbreaks of hospital-acquired infection with ESBL-producing organisms were recognized more than 20 years ago. Acquisition in nursing homes and other health care facilities was also noted. In more recent times, community-onset infections, sometimes in patients without health care contact, have been widely observed. The origins of community-acquired infection with ESBL-producing organisms is an area deserving much future study.

Original languageEnglish
Title of host publicationAntimicrobial Resistance
PublisherS. Karger AG
Pages21-34
Number of pages14
Volume6
ISBN (Electronic)9783805593243
ISBN (Print)9783805593236
DOIs
Publication statusPublished - 17-03-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Paterson, D. L., & Doi, Y. (2010). Infections with organisms producing extended-spectrum β-lactamase. In Antimicrobial Resistance (Vol. 6, pp. 21-34). S. Karger AG. https://doi.org/10.1159/000298754