Infections with organisms producing extended-spectrum β-lactamase

David L. Paterson, Yohei Doi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Extended-spectrum β-lactamases (ESBL) are enzymes produced by a variety of Gram-negative bacilli, which confer reduced susceptibility to third-generation cephalosporins and aztreonam. Resistance to other antibiotic classes (such as aminoglycosides or fluoroquinolones) is also frequently observed in ESBL-producing organisms. Outbreaks of hospital-acquired infection with ESBL-producing organisms were recognized more than 20 years ago. Acquisition in nursing homes and other health care facilities was also noted. In more recent times, community-onset infections, sometimes in patients without health care contact, have been widely observed. The origins of community-acquired infection with ESBL-producing organisms is an area deserving much future study.

Original languageEnglish
Title of host publicationAntimicrobial Resistance
PublisherS. Karger AG
Pages21-34
Number of pages14
Volume6
ISBN (Electronic)9783805593243
ISBN (Print)9783805593236
DOIs
Publication statusPublished - 17-03-2010

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Community-Acquired Infections
Aztreonam
Health Facilities
Fluoroquinolones
Aminoglycosides
Cephalosporins
Cross Infection
Nursing Homes
Bacillus
Disease Outbreaks
Anti-Bacterial Agents
Delivery of Health Care
Enzymes
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Paterson, D. L., & Doi, Y. (2010). Infections with organisms producing extended-spectrum β-lactamase. In Antimicrobial Resistance (Vol. 6, pp. 21-34). S. Karger AG. https://doi.org/10.1159/000298754
Paterson, David L. ; Doi, Yohei. / Infections with organisms producing extended-spectrum β-lactamase. Antimicrobial Resistance. Vol. 6 S. Karger AG, 2010. pp. 21-34
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Paterson, DL & Doi, Y 2010, Infections with organisms producing extended-spectrum β-lactamase. in Antimicrobial Resistance. vol. 6, S. Karger AG, pp. 21-34. https://doi.org/10.1159/000298754

Infections with organisms producing extended-spectrum β-lactamase. / Paterson, David L.; Doi, Yohei.

Antimicrobial Resistance. Vol. 6 S. Karger AG, 2010. p. 21-34.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Paterson DL, Doi Y. Infections with organisms producing extended-spectrum β-lactamase. In Antimicrobial Resistance. Vol. 6. S. Karger AG. 2010. p. 21-34 https://doi.org/10.1159/000298754