Infections with organisms producing extended-spectrum β-lactamase

David L. Paterson, Yohei Doi

Research output: Chapter in Book/Report/Conference proceedingChapter


Extended-spectrum β-lactamases (ESBL) are enzymes produced by a variety of Gram-negative bacilli, which confer reduced susceptibility to third-generation cephalosporins and aztreonam. Resistance to other antibiotic classes (such as aminoglycosides or fluoroquinolones) is also frequently observed in ESBL-producing organisms. Outbreaks of hospital-acquired infection with ESBL-producing organisms were recognized more than 20 years ago. Acquisition in nursing homes and other health care facilities was also noted. In more recent times, community-onset infections, sometimes in patients without health care contact, have been widely observed. The origins of community-acquired infection with ESBL-producing organisms is an area deserving much future study.

Original languageEnglish
Title of host publicationAntimicrobial Resistance
Subtitle of host publicationBeyond the Breakpoint
EditorsJ. Todd Weber
Number of pages14
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameIssues in Infectious Diseases
ISSN (Print)1660-1890
ISSN (Electronic)1662-3819

All Science Journal Classification (ASJC) codes

  • Infectious Diseases


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