Abstract
Kawasaki disease complicates with myocarditis and vasculitis. Even if myocarditis is asymptomatic, heterogeneity of ventricular repolarization may be increased in the acute phase. We evaluated whether the change in repolarization characteristics can be used as a predictor for myocarditis and coronary lesions. Enrolled 34 children who were treated with intravenous immunoglobulin therapy. There were no sequelae in the recovery phase in any subjects, including those who had transient coronary artery lesion. QT and the interval from the Tpeak to Tend (Tp-e) were determined. The Tp-e/QT ratios were compared between the acute and recovery phases and correlations with CRP level and body temperature were evaluated. A retrospective evaluation of Tp-e/QT as predictors of coronary dilation was also performed. Tp-e/QT in the acute phase correlated positively with body temperature and CRP level. In a comparison of patients with and without transient coronary artery lesion, Tp-e/QT was significantly higher in those with dilation. In conclusion, Tp-e/QT was strongly related to transient coronary dilation, in comparison with inflammatory indicators including fever and CRP level.
| Original language | English |
|---|---|
| Pages (from-to) | 1268-1272 |
| Number of pages | 5 |
| Journal | Pediatric Cardiology |
| DOIs | |
| Publication status | Published - 01-01-2014 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Cardiology and Cardiovascular Medicine
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Inflammation aggravates heterogeneity of ventricular repolarization in children with kawasaki disease. / Fujino, Masayuki; Hata, Tadayoshi; Kuriki, Marina; Horio, Kayo; Uchida, Hidetoshi; Eryu, Yoshihiko; Boda, Hiroko; Miyata, Masafumi; Yoshikawa, Tetsushi.
In: Pediatric Cardiology, 01.01.2014, p. 1268-1272.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inflammation aggravates heterogeneity of ventricular repolarization in children with kawasaki disease
AU - Fujino, Masayuki
AU - Hata, Tadayoshi
AU - Kuriki, Marina
AU - Horio, Kayo
AU - Uchida, Hidetoshi
AU - Eryu, Yoshihiko
AU - Boda, Hiroko
AU - Miyata, Masafumi
AU - Yoshikawa, Tetsushi
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Kawasaki disease complicates with myocarditis and vasculitis. Even if myocarditis is asymptomatic, heterogeneity of ventricular repolarization may be increased in the acute phase. We evaluated whether the change in repolarization characteristics can be used as a predictor for myocarditis and coronary lesions. Enrolled 34 children who were treated with intravenous immunoglobulin therapy. There were no sequelae in the recovery phase in any subjects, including those who had transient coronary artery lesion. QT and the interval from the Tpeak to Tend (Tp-e) were determined. The Tp-e/QT ratios were compared between the acute and recovery phases and correlations with CRP level and body temperature were evaluated. A retrospective evaluation of Tp-e/QT as predictors of coronary dilation was also performed. Tp-e/QT in the acute phase correlated positively with body temperature and CRP level. In a comparison of patients with and without transient coronary artery lesion, Tp-e/QT was significantly higher in those with dilation. In conclusion, Tp-e/QT was strongly related to transient coronary dilation, in comparison with inflammatory indicators including fever and CRP level.
AB - Kawasaki disease complicates with myocarditis and vasculitis. Even if myocarditis is asymptomatic, heterogeneity of ventricular repolarization may be increased in the acute phase. We evaluated whether the change in repolarization characteristics can be used as a predictor for myocarditis and coronary lesions. Enrolled 34 children who were treated with intravenous immunoglobulin therapy. There were no sequelae in the recovery phase in any subjects, including those who had transient coronary artery lesion. QT and the interval from the Tpeak to Tend (Tp-e) were determined. The Tp-e/QT ratios were compared between the acute and recovery phases and correlations with CRP level and body temperature were evaluated. A retrospective evaluation of Tp-e/QT as predictors of coronary dilation was also performed. Tp-e/QT in the acute phase correlated positively with body temperature and CRP level. In a comparison of patients with and without transient coronary artery lesion, Tp-e/QT was significantly higher in those with dilation. In conclusion, Tp-e/QT was strongly related to transient coronary dilation, in comparison with inflammatory indicators including fever and CRP level.
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UR - http://www.scopus.com/inward/citedby.url?scp=84929940439&partnerID=8YFLogxK
U2 - 10.1007/s00246-014-0926-2
DO - 10.1007/s00246-014-0926-2
M3 - Article
C2 - 24823886
AN - SCOPUS:84929940439
SP - 1268
EP - 1272
JO - Pediatric Cardiology
JF - Pediatric Cardiology
SN - 0172-0643
ER -