Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes

Hiroshi Nagasaki; Takaaki Kondo; Masahiro Fuchigami; Hiroyuki Hashimoto; Yoshihisa Sugimura; Nobuaki Ozaki; Hiroshi Arima; Akira Ota; Yutaka Oiso; Yoji Hamada

doi:10.1016/j.febslet.2012.01.001

Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes

Hiroshi Nagasaki, Takaaki Kondo, Masahiro Fuchigami, Hiroyuki Hashimoto, Yoshihisa Sugimura, Nobuaki Ozaki, Hiroshi Arima, Akira Ota, Yutaka Oiso, Yoji Hamada

Physiology Ⅰ

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.

Original language	English
Pages (from-to)	368-372
Number of pages	5
Journal	FEBS Letters
Volume	586
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2012.01.001
Publication status	Published - 17-02-2012

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Nagasaki, Hiroshi ; Kondo, Takaaki ; Fuchigami, Masahiro ; Hashimoto, Hiroyuki ; Sugimura, Yoshihisa ; Ozaki, Nobuaki ; Arima, Hiroshi ; Ota, Akira ; Oiso, Yutaka ; Hamada, Yoji. / Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor : TNFα enhances GPR84 expression in adipocytes. In: FEBS Letters. 2012 ; Vol. 586, No. 4. pp. 368-372.

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abstract = "In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.",

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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor : TNFα enhances GPR84 expression in adipocytes. / Nagasaki, Hiroshi; Kondo, Takaaki; Fuchigami, Masahiro; Hashimoto, Hiroyuki; Sugimura, Yoshihisa; Ozaki, Nobuaki; Arima, Hiroshi; Ota, Akira; Oiso, Yutaka; Hamada, Yoji.

In: FEBS Letters, Vol. 586, No. 4, 17.02.2012, p. 368-372.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Nagasaki, Hiroshi

AU - Kondo, Takaaki

AU - Fuchigami, Masahiro

AU - Hashimoto, Hiroyuki

AU - Sugimura, Yoshihisa

AU - Ozaki, Nobuaki

AU - Arima, Hiroshi

AU - Ota, Akira

AU - Oiso, Yutaka

AU - Hamada, Yoji

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