Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor

TNFα enhances GPR84 expression in adipocytes

Hiroshi Nagasaki, Takaaki Kondo, Masahiro Fuchigami, Hiroyuki Hashimoto, Yoshihisa Sugimura, Nobuaki Ozaki, Hiroshi Arima, Akira Ota, Yutaka Oiso, Yoji Hamada

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalFEBS Letters
Volume586
Issue number4
DOIs
Publication statusPublished - 17-02-2012

Fingerprint

Tumor Necrosis Factor Receptors
G-Protein-Coupled Receptors
Adipocytes
Adipose Tissue
Fatty Acids
Tissue
Macrophages
Fats
Adiponectin
Adiposity
High Fat Diet
Nutrition
Coculture Techniques
Cell culture
Cells
Ligands
Cell Line
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Nagasaki, Hiroshi ; Kondo, Takaaki ; Fuchigami, Masahiro ; Hashimoto, Hiroyuki ; Sugimura, Yoshihisa ; Ozaki, Nobuaki ; Arima, Hiroshi ; Ota, Akira ; Oiso, Yutaka ; Hamada, Yoji. / Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor : TNFα enhances GPR84 expression in adipocytes. In: FEBS Letters. 2012 ; Vol. 586, No. 4. pp. 368-372.
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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor : TNFα enhances GPR84 expression in adipocytes. / Nagasaki, Hiroshi; Kondo, Takaaki; Fuchigami, Masahiro; Hashimoto, Hiroyuki; Sugimura, Yoshihisa; Ozaki, Nobuaki; Arima, Hiroshi; Ota, Akira; Oiso, Yutaka; Hamada, Yoji.

In: FEBS Letters, Vol. 586, No. 4, 17.02.2012, p. 368-372.

Research output: Contribution to journalArticle

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AU - Nagasaki, Hiroshi

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AU - Hashimoto, Hiroyuki

AU - Sugimura, Yoshihisa

AU - Ozaki, Nobuaki

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AU - Hamada, Yoji

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