Abstract
In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
| Original language | English |
|---|---|
| Pages (from-to) | 368-372 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 586 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 17-02-2012 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor : TNFα enhances GPR84 expression in adipocytes. / Nagasaki, Hiroshi; Kondo, Takaaki; Fuchigami, Masahiro; Hashimoto, Hiroyuki; Sugimura, Yoshihisa; Ozaki, Nobuaki; Arima, Hiroshi; Ota, Akira; Oiso, Yutaka; Hamada, Yoji.
In: FEBS Letters, Vol. 586, No. 4, 17.02.2012, p. 368-372.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor
T2 - TNFα enhances GPR84 expression in adipocytes
AU - Nagasaki, Hiroshi
AU - Kondo, Takaaki
AU - Fuchigami, Masahiro
AU - Hashimoto, Hiroyuki
AU - Sugimura, Yoshihisa
AU - Ozaki, Nobuaki
AU - Arima, Hiroshi
AU - Ota, Akira
AU - Oiso, Yutaka
AU - Hamada, Yoji
PY - 2012/2/17
Y1 - 2012/2/17
N2 - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
AB - In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
UR - http://www.scopus.com/inward/record.url?scp=84857051975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857051975&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2012.01.001
DO - 10.1016/j.febslet.2012.01.001
M3 - Article
VL - 586
SP - 368
EP - 372
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 4
ER -