Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki; Naoto Nakagawa; Hitoshi Nakamura; Takanori Hishinuma; Yoshihisa Tomioka; Shunji Ishiwata; Tatsuo Ido; Ren Iwata; Yoshihito Funaki; Masatoshi Itoh; Masato Higuchi; Nobuyuki Okamura; Takehiko Fujiwara; Mitsutomo Sato; Katsuhiro Shindo; Sumiko Yoshida

doi:10.1016/S0006-8993(01)02669-5

Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki, Naoto Nakagawa, Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Shunji Ishiwata, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Masato Higuchi, Nobuyuki Okamura, Takehiko Fujiwara, Mitsutomo Sato, Katsuhiro Shindo, Sumiko Yoshida

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We investigated the influence of anesthesia on the brain distribution of [¹¹C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [¹¹C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Brain Research
Volume	911
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02669-5
Publication status	Published - 24-08-2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(01)02669-5

Cite this

Mizugaki, M., Nakagawa, N., Nakamura, H., Hishinuma, T., Tomioka, Y., Ishiwata, S., Ido, T., Iwata, R., Funaki, Y., Itoh, M., Higuchi, M., Okamura, N., Fujiwara, T., Sato, M., Shindo, K., & Yoshida, S. (2001). Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study. Brain Research, 911(2), 173-175. https://doi.org/10.1016/S0006-8993(01)02669-5

@article{3b8ed3d40b8d4c029207fbbbee81da30,

title = "Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study",

abstract = "We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.",

author = "Michinao Mizugaki and Naoto Nakagawa and Hitoshi Nakamura and Takanori Hishinuma and Yoshihisa Tomioka and Shunji Ishiwata and Tatsuo Ido and Ren Iwata and Yoshihito Funaki and Masatoshi Itoh and Masato Higuchi and Nobuyuki Okamura and Takehiko Fujiwara and Mitsutomo Sato and Katsuhiro Shindo and Sumiko Yoshida",

year = "2001",

month = aug,

day = "24",

doi = "10.1016/S0006-8993(01)02669-5",

language = "English",

volume = "911",

pages = "173--175",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "2",

}

Mizugaki, M, Nakagawa, N, Nakamura, H, Hishinuma, T, Tomioka, Y, Ishiwata, S, Ido, T, Iwata, R, Funaki, Y, Itoh, M, Higuchi, M, Okamura, N, Fujiwara, T, Sato, M, Shindo, K & Yoshida, S 2001, 'Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study', Brain Research, vol. 911, no. 2, pp. 173-175. https://doi.org/10.1016/S0006-8993(01)02669-5

TY - JOUR

T1 - Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

AU - Mizugaki, Michinao

AU - Nakagawa, Naoto

AU - Nakamura, Hitoshi

AU - Hishinuma, Takanori

AU - Tomioka, Yoshihisa

AU - Ishiwata, Shunji

AU - Ido, Tatsuo

AU - Iwata, Ren

AU - Funaki, Yoshihito

AU - Itoh, Masatoshi

AU - Higuchi, Masato

AU - Okamura, Nobuyuki

AU - Fujiwara, Takehiko

AU - Sato, Mitsutomo

AU - Shindo, Katsuhiro

AU - Yoshida, Sumiko

PY - 2001/8/24

Y1 - 2001/8/24

N2 - We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

AB - We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

UR - http://www.scopus.com/inward/record.url?scp=17944382799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17944382799&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(01)02669-5

DO - 10.1016/S0006-8993(01)02669-5

M3 - Article

C2 - 11511387

AN - SCOPUS:17944382799

SN - 0006-8993

VL - 911

SP - 173

EP - 175

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this