TY - JOUR
T1 - Influence of basic fibroblast growth factor on in vivo endothelialization and healing of expanded polytetrafluoroethylene grafts
AU - Nakanishi, Kenichi
AU - Yamamura, Keiko
AU - Sakurai, Tsunehisa
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2003
Y1 - 2003
N2 - Although it is known that basic fibroblast growth factor (bFGF) is an endothelial cell mitogen and chemoattractant, how it affects in vivo endothelialization and healing of expanded polytetrafluoroethylene (ePTFE) grafts has not been delineated. This study was conducted to evaluate the effect of bFGF on endothelialization of ePTFE vascular prostheses. Non-reinforced ePTFE grafts (30-mm length, 5-mm inner diameter, 30-μm internodal distance) soaked in recombinant bFGF solution and non-treated ePTFE grafts were implanted in 10 mongrel dogs between the femoral arteries and veins. The grafts were harvested at 8 weeks and stained with hematoxylin and eosin for light microscopy. Compared with the control grafts, the bFGF grafts exhibited more confluently endothelialized luminal surfaces and a thicker surrounding connective tissue layer. Basic FGF promotes luminal endothelialization and healing of ePTFE grafts.
AB - Although it is known that basic fibroblast growth factor (bFGF) is an endothelial cell mitogen and chemoattractant, how it affects in vivo endothelialization and healing of expanded polytetrafluoroethylene (ePTFE) grafts has not been delineated. This study was conducted to evaluate the effect of bFGF on endothelialization of ePTFE vascular prostheses. Non-reinforced ePTFE grafts (30-mm length, 5-mm inner diameter, 30-μm internodal distance) soaked in recombinant bFGF solution and non-treated ePTFE grafts were implanted in 10 mongrel dogs between the femoral arteries and veins. The grafts were harvested at 8 weeks and stained with hematoxylin and eosin for light microscopy. Compared with the control grafts, the bFGF grafts exhibited more confluently endothelialized luminal surfaces and a thicker surrounding connective tissue layer. Basic FGF promotes luminal endothelialization and healing of ePTFE grafts.
UR - https://www.scopus.com/pages/publications/4444231385
UR - https://www.scopus.com/inward/citedby.url?scp=4444231385&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:4444231385
SN - 1029-2659
VL - 4
SP - 21
EP - 26
JO - Journal of Applied Therapeutic Research
JF - Journal of Applied Therapeutic Research
IS - 1
ER -