Influence of genetic variants in EGF and other genes on hematological traits in Korean populations by a genome-wide approach

Yun Kyoung Kim, Ji Hee Oh, Young Jin Kim, Mi Yeong Hwang, Sanghoon Moon, Siew Kee Low, Atsushi Takahashi, Koichi Matsuda, Michiaki Kubo, Juyoung Lee, Bong Jo Kim, Amelie Bonnefond

Research output: Contribution to journalArticle

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Abstract

Hematological traits are important health indicators and are used as diagnostic clinical parameters for human disorders. Recently, genome-wide association studies (GWAS) identified many genetic loci associated with hematological traits in diverse ethnic groups. However, additional GWAS are necessary to elucidate the breadth of genetic variation and the underlying genetic architecture represented by hematological metrics. To identify additional genetic loci influencing hematological traits (such as hematocrit, hemoglobin concentration, white blood cell count, red blood cell count, and platelet count), we conducted GWAS and meta-analyses on data from 12,509 Korean individuals grouped into population-based cohorts. Of interest is EGF, a factor plays a role in the proliferation and differentiation of hematopoietic progenitor cells. We identified a novel EGF variant, which associated with platelet count in our study (Pcombined=2.44×10-15). Our study also replicated 16 genetic associations related to five hematological traits with genome-wide significance (P<5×10-8) that were previously established in other ethnic groups. Of these, variants influencing platelet count are distributed across several genes and have pleiotropic effects in coronary artery disease and dyslipidemia. Our findings may aid in elucidating molecular mechanisms underlying not only hematopoiesis but also inflammatory and cardiovascular diseases.

Original languageEnglish
Article number914965
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

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Genome-Wide Association Study
Platelet Count
Epidermal Growth Factor
Genetic Loci
Genes
Genome
Ethnic Groups
Platelets
Genetic Pleiotropy
Population
Erythrocyte Count
Hematopoiesis
Dyslipidemias
Hematopoietic Stem Cells
Leukocyte Count
Hematocrit
Blood
Cells
Meta-Analysis
Coronary Artery Disease

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Kim, Yun Kyoung ; Oh, Ji Hee ; Kim, Young Jin ; Hwang, Mi Yeong ; Moon, Sanghoon ; Low, Siew Kee ; Takahashi, Atsushi ; Matsuda, Koichi ; Kubo, Michiaki ; Lee, Juyoung ; Kim, Bong Jo ; Bonnefond, Amelie. / Influence of genetic variants in EGF and other genes on hematological traits in Korean populations by a genome-wide approach. In: BioMed Research International. 2015 ; Vol. 2015.
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Kim, YK, Oh, JH, Kim, YJ, Hwang, MY, Moon, S, Low, SK, Takahashi, A, Matsuda, K, Kubo, M, Lee, J, Kim, BJ & Bonnefond, A 2015, 'Influence of genetic variants in EGF and other genes on hematological traits in Korean populations by a genome-wide approach', BioMed Research International, vol. 2015, 914965. https://doi.org/10.1155/2015/914965

Influence of genetic variants in EGF and other genes on hematological traits in Korean populations by a genome-wide approach. / Kim, Yun Kyoung; Oh, Ji Hee; Kim, Young Jin; Hwang, Mi Yeong; Moon, Sanghoon; Low, Siew Kee; Takahashi, Atsushi; Matsuda, Koichi; Kubo, Michiaki; Lee, Juyoung; Kim, Bong Jo; Bonnefond, Amelie.

In: BioMed Research International, Vol. 2015, 914965, 01.01.2015.

Research output: Contribution to journalArticle

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AU - Kim, Yun Kyoung

AU - Oh, Ji Hee

AU - Kim, Young Jin

AU - Hwang, Mi Yeong

AU - Moon, Sanghoon

AU - Low, Siew Kee

AU - Takahashi, Atsushi

AU - Matsuda, Koichi

AU - Kubo, Michiaki

AU - Lee, Juyoung

AU - Kim, Bong Jo

AU - Bonnefond, Amelie

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N2 - Hematological traits are important health indicators and are used as diagnostic clinical parameters for human disorders. Recently, genome-wide association studies (GWAS) identified many genetic loci associated with hematological traits in diverse ethnic groups. However, additional GWAS are necessary to elucidate the breadth of genetic variation and the underlying genetic architecture represented by hematological metrics. To identify additional genetic loci influencing hematological traits (such as hematocrit, hemoglobin concentration, white blood cell count, red blood cell count, and platelet count), we conducted GWAS and meta-analyses on data from 12,509 Korean individuals grouped into population-based cohorts. Of interest is EGF, a factor plays a role in the proliferation and differentiation of hematopoietic progenitor cells. We identified a novel EGF variant, which associated with platelet count in our study (Pcombined=2.44×10-15). Our study also replicated 16 genetic associations related to five hematological traits with genome-wide significance (P<5×10-8) that were previously established in other ethnic groups. Of these, variants influencing platelet count are distributed across several genes and have pleiotropic effects in coronary artery disease and dyslipidemia. Our findings may aid in elucidating molecular mechanisms underlying not only hematopoiesis but also inflammatory and cardiovascular diseases.

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