Influence of MDR1 polymorphism on H. pylori-related chronic gastritis

Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Ichiro Hirata, Tomiyasu Arisawa

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Background: There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract. Aims: We aimed to investigate the effect of C3435T polymorphism of the MDR1 gene on histological chronic gastritis, and on the risk of peptic ulcer diseases. Methods: Restriction fragment length polymorphism analysis was performed for polymorphisms at C3435T in the MDR1 gene in 556 cancer-free subjects including 116 gastric and 60 duodenal ulcers, and 380 non-ulcer subjects. Gastritis scores in the antrum were assessed according to the updated Sydney system in 384 subjects. Results: We did not find a significant association between MDR1 genotype and gastritis scores in any of the 384 subjects. However, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in H. pylori-positive subjects (CC vs. T carrier: p = 0.0495). When the H. pylori positive subjects were divided according to generation, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in subjects more than 65 years of age (CC vs. T carrier: p = 0.03). Also, the MDR1 3435 TT genotype was significantly associated with a higher degree of atrophy and intestinal metaplasia in the same generation (atrophy, TT vs. C carrier: p = 0.038, intestinal metaplasia, TT vs. C carrier: p = 0.016). No association was found between MDR1 genotypes and risk of peptic ulcer diseases. Conclusions: It appears that the C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalDigestive Diseases and Sciences
Volume56
Issue number1
DOIs
Publication statusPublished - 01-01-2011

Fingerprint

Pylorus
Gastritis
Neutrophil Infiltration
Genotype
Metaplasia
Peptic Ulcer
Atrophy
Stomach
Duodenal Ulcer
Restriction Fragment Length Polymorphisms
Genes
Gastrointestinal Tract
Neoplasms

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Physiology

Cite this

Tahara, Tomomitsu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Hirata, Ichiro ; Arisawa, Tomiyasu. / Influence of MDR1 polymorphism on H. pylori-related chronic gastritis. In: Digestive Diseases and Sciences. 2011 ; Vol. 56, No. 1. pp. 103-108.
@article{1ded32ad07314b58b968d167a1ff690f,
title = "Influence of MDR1 polymorphism on H. pylori-related chronic gastritis",
abstract = "Background: There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract. Aims: We aimed to investigate the effect of C3435T polymorphism of the MDR1 gene on histological chronic gastritis, and on the risk of peptic ulcer diseases. Methods: Restriction fragment length polymorphism analysis was performed for polymorphisms at C3435T in the MDR1 gene in 556 cancer-free subjects including 116 gastric and 60 duodenal ulcers, and 380 non-ulcer subjects. Gastritis scores in the antrum were assessed according to the updated Sydney system in 384 subjects. Results: We did not find a significant association between MDR1 genotype and gastritis scores in any of the 384 subjects. However, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in H. pylori-positive subjects (CC vs. T carrier: p = 0.0495). When the H. pylori positive subjects were divided according to generation, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in subjects more than 65 years of age (CC vs. T carrier: p = 0.03). Also, the MDR1 3435 TT genotype was significantly associated with a higher degree of atrophy and intestinal metaplasia in the same generation (atrophy, TT vs. C carrier: p = 0.038, intestinal metaplasia, TT vs. C carrier: p = 0.016). No association was found between MDR1 genotypes and risk of peptic ulcer diseases. Conclusions: It appears that the C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.",
author = "Tomomitsu Tahara and Tomoyuki Shibata and Hiromi Yamashita and Ichiro Hirata and Tomiyasu Arisawa",
year = "2011",
month = "1",
day = "1",
doi = "10.1007/s10620-010-1251-0",
language = "English",
volume = "56",
pages = "103--108",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "1",

}

Influence of MDR1 polymorphism on H. pylori-related chronic gastritis. / Tahara, Tomomitsu; Shibata, Tomoyuki; Yamashita, Hiromi; Hirata, Ichiro; Arisawa, Tomiyasu.

In: Digestive Diseases and Sciences, Vol. 56, No. 1, 01.01.2011, p. 103-108.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Influence of MDR1 polymorphism on H. pylori-related chronic gastritis

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Yamashita, Hiromi

AU - Hirata, Ichiro

AU - Arisawa, Tomiyasu

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract. Aims: We aimed to investigate the effect of C3435T polymorphism of the MDR1 gene on histological chronic gastritis, and on the risk of peptic ulcer diseases. Methods: Restriction fragment length polymorphism analysis was performed for polymorphisms at C3435T in the MDR1 gene in 556 cancer-free subjects including 116 gastric and 60 duodenal ulcers, and 380 non-ulcer subjects. Gastritis scores in the antrum were assessed according to the updated Sydney system in 384 subjects. Results: We did not find a significant association between MDR1 genotype and gastritis scores in any of the 384 subjects. However, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in H. pylori-positive subjects (CC vs. T carrier: p = 0.0495). When the H. pylori positive subjects were divided according to generation, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in subjects more than 65 years of age (CC vs. T carrier: p = 0.03). Also, the MDR1 3435 TT genotype was significantly associated with a higher degree of atrophy and intestinal metaplasia in the same generation (atrophy, TT vs. C carrier: p = 0.038, intestinal metaplasia, TT vs. C carrier: p = 0.016). No association was found between MDR1 genotypes and risk of peptic ulcer diseases. Conclusions: It appears that the C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.

AB - Background: There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract. Aims: We aimed to investigate the effect of C3435T polymorphism of the MDR1 gene on histological chronic gastritis, and on the risk of peptic ulcer diseases. Methods: Restriction fragment length polymorphism analysis was performed for polymorphisms at C3435T in the MDR1 gene in 556 cancer-free subjects including 116 gastric and 60 duodenal ulcers, and 380 non-ulcer subjects. Gastritis scores in the antrum were assessed according to the updated Sydney system in 384 subjects. Results: We did not find a significant association between MDR1 genotype and gastritis scores in any of the 384 subjects. However, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in H. pylori-positive subjects (CC vs. T carrier: p = 0.0495). When the H. pylori positive subjects were divided according to generation, the 3435T carrier was significantly associated with a higher degree of neutrophil infiltration in subjects more than 65 years of age (CC vs. T carrier: p = 0.03). Also, the MDR1 3435 TT genotype was significantly associated with a higher degree of atrophy and intestinal metaplasia in the same generation (atrophy, TT vs. C carrier: p = 0.038, intestinal metaplasia, TT vs. C carrier: p = 0.016). No association was found between MDR1 genotypes and risk of peptic ulcer diseases. Conclusions: It appears that the C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.

UR - http://www.scopus.com/inward/record.url?scp=79151469303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79151469303&partnerID=8YFLogxK

U2 - 10.1007/s10620-010-1251-0

DO - 10.1007/s10620-010-1251-0

M3 - Review article

C2 - 20464493

AN - SCOPUS:79151469303

VL - 56

SP - 103

EP - 108

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 1

ER -