Influence of Mild Cognitive Impairment on LSVT^® BIG Therapy Effectiveness in People with Parkinson’s Disease: A Retrospective Cohort Study

Aim: To investigate the influence of cognitive functions on the effectiveness of Lee Silverman Voice Treatment (LSVT)^® BIG therapy on motor symptoms, gait speed, activities of daily living (ADLs), and quality of life (QOL) in people with Parkinson’s disease (PD). Methods: This retrospective, single-center cohort study included 20 people with PD (PwPD) with mild cognitive impairment (PD-MCI group) or without (PD-NC group) (n = 10 each). Results: In the PD-NC group, all assessments improved significantly. Similarly, the PD-MCI group showed significant improvements in the total Movement Disorder Society‐sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III, 10-meter walking test, and total MDS-UPDRS Part II. However, the Parkinson’s Disease Questionnaire summary index showed a trend toward improvement that did not reach statistical significance. Conclusions: LSVT^® BIG therapy may improve motor symptoms, gait speed, and ADLs in PwPD, regardless of the presence or absence of MCI.