TY - JOUR
T1 - Inhalation of calcium channel blocking agents protects against methacholine-induced bronchoconstriction
AU - Tsuda, Takako
AU - Hatta, Makoto
AU - Ishikawa, Kiyoshi
AU - Nakagawa, Takashi
AU - Mabuchi, Norihumi
AU - Ando, Hiroshi
AU - Nishida, Osamu
PY - 1993/10
Y1 - 1993/10
N2 - The calcium channel blockers, diltiazem and verapamil, and the beta agonist orciprenaline sulfate all demonstrated significant protection against methacholine-induced bronchoconstriction in 11 stable asthmatics (5 males and 6 females). Ten and 20 mg of inhaled diltiazem, 5 mg of verapamil or 30 mg of orciprenaline administered 15 min before stepwise increasing doses of methacholine hydrochloride produced significant reduction in respiratory resistance (Rrs), minimum dose of methacholine hydrochloride required for Rrs increase (Dmin) and bronchial reactivity measured with an Astograph. The mechanism of action of the calcium channel blockers is presumably at the level of the smooth muscle cells themselves. The combination of positive influence and lack of any adverse effect on blood pressure or heart rate with any of the agents tested indicates that their clinical application for alleviation of acute asthma can be recommended.
AB - The calcium channel blockers, diltiazem and verapamil, and the beta agonist orciprenaline sulfate all demonstrated significant protection against methacholine-induced bronchoconstriction in 11 stable asthmatics (5 males and 6 females). Ten and 20 mg of inhaled diltiazem, 5 mg of verapamil or 30 mg of orciprenaline administered 15 min before stepwise increasing doses of methacholine hydrochloride produced significant reduction in respiratory resistance (Rrs), minimum dose of methacholine hydrochloride required for Rrs increase (Dmin) and bronchial reactivity measured with an Astograph. The mechanism of action of the calcium channel blockers is presumably at the level of the smooth muscle cells themselves. The combination of positive influence and lack of any adverse effect on blood pressure or heart rate with any of the agents tested indicates that their clinical application for alleviation of acute asthma can be recommended.
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U2 - 10.1007/s0054030070397
DO - 10.1007/s0054030070397
M3 - Article
C2 - 15278788
AN - SCOPUS:0027488860
SN - 0913-8668
VL - 7
SP - 397
EP - 404
JO - Journal of Anesthesia
JF - Journal of Anesthesia
IS - 4
ER -