Inhalation of calcium channel blocking agents protects against methacholine-induced bronchoconstriction

Takako Tsuda, Makoto Hatta, Kiyoshi Ishikawa, Takashi Nakagawa, Norihumi Mabuchi, Hiroshi Ando, Osamu Nishida

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The calcium channel blockers, diltiazem and verapamil, and the beta agonist orciprenaline sulfate all demonstrated significant protection against methacholine-induced bronchoconstriction in 11 stable asthmatics (5 males and 6 females). Ten and 20 mg of inhaled diltiazem, 5 mg of verapamil or 30 mg of orciprenaline administered 15 min before stepwise increasing doses of methacholine hydrochloride produced significant reduction in respiratory resistance (Rrs), minimum dose of methacholine hydrochloride required for Rrs increase (Dmin) and bronchial reactivity measured with an Astograph. The mechanism of action of the calcium channel blockers is presumably at the level of the smooth muscle cells themselves. The combination of positive influence and lack of any adverse effect on blood pressure or heart rate with any of the agents tested indicates that their clinical application for alleviation of acute asthma can be recommended.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalJournal of Anesthesia
Issue number4
Publication statusPublished - 10-1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Inhalation of calcium channel blocking agents protects against methacholine-induced bronchoconstriction'. Together they form a unique fingerprint.

Cite this