Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Mitsuo Miyazawa; Hirotoshi Utsunomiya; Ken Ichi Inada; Tomoki Yamada; Yoshiharu Okuno; Harunari Tanaka; Masae Tatematsu

doi:10.1248/bpb.29.172

Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Mitsuo Miyazawa
, Hirotoshi Utsunomiya
, Ken Ichi Inada
, Tomoki Yamada
, Yoshiharu Okuno
, Harunari Tanaka
, Masae Tatematsu

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC₅₀ value was 50 μg/ml.

Original language	English
Pages (from-to)	172-173
Number of pages	2
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	1
DOIs	https://doi.org/10.1248/bpb.29.172
Publication status	Published - 01-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/bpb.29.172

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abstract = "A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90\% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.",

keywords = "(+)-syringaresinol, Helicobacter pylori, Japanese apricot",

author = "Mitsuo Miyazawa and Hirotoshi Utsunomiya and Inada, \{Ken Ichi\} and Tomoki Yamada and Yoshiharu Okuno and Harunari Tanaka and Masae Tatematsu",

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AU - Miyazawa, Mitsuo

AU - Utsunomiya, Hirotoshi

AU - Inada, Ken Ichi

AU - Yamada, Tomoki

AU - Okuno, Yoshiharu

AU - Tanaka, Harunari

AU - Tatematsu, Masae

PY - 2006/1

Y1 - 2006/1

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AB - A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.

KW - (+)-syringaresinol

KW - Helicobacter pylori

KW - Japanese apricot

UR - https://www.scopus.com/pages/publications/29844441430

UR - https://www.scopus.com/pages/publications/29844441430#tab=citedBy

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JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 1

ER -

Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Abstract

All Science Journal Classification (ASJC) codes

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