Inhibition of murine AIDS (MAIDS) development by the transplantation of bone marrow cells carrying the Fv-4 resistance gene to MAIDS virus-infected mice

Yoshiaki Nakagawa, Kazuhiro Kakimi, Wang Ling, Yoshinao Kubo, Kyoko Higo, Toru Masuda, Kagemasa Kuribayashi, Michihiro Iwashiro, Yosuke Komatz, Toshiyasu Hirama, Akio Adachi, Akinori Ishimoto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

To examine whether the resistance allele of the Fv-4 gene (the Fv-4(r) gene) is a dominant inhibitory-product-encoding gene which can be used to prevent the development of murine AIDS (MAIDS), bone marrow cells from BALB/c-Fv-4w(r) mice were transplanted into BALB/c mice and C57BL/6 mice infected with MAIDS virus. Almost all of the virus-infected BALB/c and C57BL/6 mice developed MAIDS within 4 months and died 2 or 3 months later. However, when the virus-infected mice were subjected to cobalt irradiation and then given an intravenous injection of 107 BALB/c-Fv-4w(r) mouse bone marrow cells, the recipient mice survived much longer than the untreated mice, which suggests that the Fv-4 gene is a dominant inhibitory gene that is potentially useful in gene therapy of MAIDS.

Original languageEnglish
Pages (from-to)1438-1441
Number of pages4
JournalJournal of Virology
Volume68
Issue number3
DOIs
Publication statusPublished - 03-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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