Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger

Takeshi Chihara, Kan Shimpo, Masanori Shinzato, Hidehiko Beppu, Takaaki Kaneko, Chikako Ida, Kaoru Kawai, Iwao Hirono, Mikihiro Shamoto, Toshiharu Nagatsu, Hiroshi Kuzuya

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Abstract

We examined the modifying effects of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') onN-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumorigenesis in C57BL/ 6 mice. Experiment 1: Male mice were given ENNG in drinking water for the first 4 weeks, and then 10% ALOE in basal diet for 16 weeks. Experiment 2: Female mice were given ENNG for 5 weeks, and then 5%, 1% or 0.2% ALOE in the diet were given for 15 weeks. In Experiment 1, the tumor incidence and tumor multiplicity (tumors per mouse) of the duodenum in the ENNG + 10% ALOE group were significantly decreased compared with that in the ENNG alone group. Erythrocyte polyamine levels in the ENNG + 10% ALOE group were also significantly decreased. In Experiment 2, the incidence of duodenal tumors in the ENNG + 5% ALOE group were significantly decreased compared with that in the ENNG alone group. These results indicated that ALOE, especially at 10% in the diet, inhibits ENNG-induced duodenal tumorigenesis in mice.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume1
Issue number4
Publication statusPublished - 01-01-2000

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Chihara, T., Shimpo, K., Shinzato, M., Beppu, H., Kaneko, T., Ida, C., Kawai, K., Hirono, I., Shamoto, M., Nagatsu, T., & Kuzuya, H. (2000). Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger. Asian Pacific Journal of Cancer Prevention, 1(4), 283-288.