Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger

Takeshi Chihara, Kan Shimpo, Masanori Shinzato, Hidehiko Beppu, Takaaki Kaneko, Chikako Ida, Kaoru Kawai, Iwao Hirono, Mikihiro Shamoto, Toshiharu Nagatsu, Hiroshi Kuzuya

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Abstract

We examined the modifying effects of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') onN-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumorigenesis in C57BL/ 6 mice. Experiment 1: Male mice were given ENNG in drinking water for the first 4 weeks, and then 10% ALOE in basal diet for 16 weeks. Experiment 2: Female mice were given ENNG for 5 weeks, and then 5%, 1% or 0.2% ALOE in the diet were given for 15 weeks. In Experiment 1, the tumor incidence and tumor multiplicity (tumors per mouse) of the duodenum in the ENNG + 10% ALOE group were significantly decreased compared with that in the ENNG alone group. Erythrocyte polyamine levels in the ENNG + 10% ALOE group were also significantly decreased. In Experiment 2, the incidence of duodenal tumors in the ENNG + 5% ALOE group were significantly decreased compared with that in the ENNG alone group. These results indicated that ALOE, especially at 10% in the diet, inhibits ENNG-induced duodenal tumorigenesis in mice.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume1
Issue number4
Publication statusPublished - 01-01-2000

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Aloe
Carcinogenesis
Diet
Neoplasms
ENNG
Incidence
Polyamines
Inbred C57BL Mouse
Duodenum
Drinking Water
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Chihara, Takeshi ; Shimpo, Kan ; Shinzato, Masanori ; Beppu, Hidehiko ; Kaneko, Takaaki ; Ida, Chikako ; Kawai, Kaoru ; Hirono, Iwao ; Shamoto, Mikihiro ; Nagatsu, Toshiharu ; Kuzuya, Hiroshi. / Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger. In: Asian Pacific Journal of Cancer Prevention. 2000 ; Vol. 1, No. 4. pp. 283-288.
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abstract = "We examined the modifying effects of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') onN-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumorigenesis in C57BL/ 6 mice. Experiment 1: Male mice were given ENNG in drinking water for the first 4 weeks, and then 10{\%} ALOE in basal diet for 16 weeks. Experiment 2: Female mice were given ENNG for 5 weeks, and then 5{\%}, 1{\%} or 0.2{\%} ALOE in the diet were given for 15 weeks. In Experiment 1, the tumor incidence and tumor multiplicity (tumors per mouse) of the duodenum in the ENNG + 10{\%} ALOE group were significantly decreased compared with that in the ENNG alone group. Erythrocyte polyamine levels in the ENNG + 10{\%} ALOE group were also significantly decreased. In Experiment 2, the incidence of duodenal tumors in the ENNG + 5{\%} ALOE group were significantly decreased compared with that in the ENNG alone group. These results indicated that ALOE, especially at 10{\%} in the diet, inhibits ENNG-induced duodenal tumorigenesis in mice.",
author = "Takeshi Chihara and Kan Shimpo and Masanori Shinzato and Hidehiko Beppu and Takaaki Kaneko and Chikako Ida and Kaoru Kawai and Iwao Hirono and Mikihiro Shamoto and Toshiharu Nagatsu and Hiroshi Kuzuya",
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Chihara, T, Shimpo, K, Shinzato, M, Beppu, H, Kaneko, T, Ida, C, Kawai, K, Hirono, I, Shamoto, M, Nagatsu, T & Kuzuya, H 2000, 'Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger', Asian Pacific Journal of Cancer Prevention, vol. 1, no. 4, pp. 283-288.

Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger. / Chihara, Takeshi; Shimpo, Kan; Shinzato, Masanori; Beppu, Hidehiko; Kaneko, Takaaki; Ida, Chikako; Kawai, Kaoru; Hirono, Iwao; Shamoto, Mikihiro; Nagatsu, Toshiharu; Kuzuya, Hiroshi.

In: Asian Pacific Journal of Cancer Prevention, Vol. 1, No. 4, 01.01.2000, p. 283-288.

Research output: Contribution to journalArticle

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T1 - Inhibition of N-ethyl-N'-nitro-N-nitrosoguanidine-induced Duodenal Tumorigenesis in Mice by whole-leaf aloe arborescens miller var. natalensis berger

AU - Chihara, Takeshi

AU - Shimpo, Kan

AU - Shinzato, Masanori

AU - Beppu, Hidehiko

AU - Kaneko, Takaaki

AU - Ida, Chikako

AU - Kawai, Kaoru

AU - Hirono, Iwao

AU - Shamoto, Mikihiro

AU - Nagatsu, Toshiharu

AU - Kuzuya, Hiroshi

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We examined the modifying effects of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') onN-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumorigenesis in C57BL/ 6 mice. Experiment 1: Male mice were given ENNG in drinking water for the first 4 weeks, and then 10% ALOE in basal diet for 16 weeks. Experiment 2: Female mice were given ENNG for 5 weeks, and then 5%, 1% or 0.2% ALOE in the diet were given for 15 weeks. In Experiment 1, the tumor incidence and tumor multiplicity (tumors per mouse) of the duodenum in the ENNG + 10% ALOE group were significantly decreased compared with that in the ENNG alone group. Erythrocyte polyamine levels in the ENNG + 10% ALOE group were also significantly decreased. In Experiment 2, the incidence of duodenal tumors in the ENNG + 5% ALOE group were significantly decreased compared with that in the ENNG alone group. These results indicated that ALOE, especially at 10% in the diet, inhibits ENNG-induced duodenal tumorigenesis in mice.

AB - We examined the modifying effects of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') onN-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced duodenal tumorigenesis in C57BL/ 6 mice. Experiment 1: Male mice were given ENNG in drinking water for the first 4 weeks, and then 10% ALOE in basal diet for 16 weeks. Experiment 2: Female mice were given ENNG for 5 weeks, and then 5%, 1% or 0.2% ALOE in the diet were given for 15 weeks. In Experiment 1, the tumor incidence and tumor multiplicity (tumors per mouse) of the duodenum in the ENNG + 10% ALOE group were significantly decreased compared with that in the ENNG alone group. Erythrocyte polyamine levels in the ENNG + 10% ALOE group were also significantly decreased. In Experiment 2, the incidence of duodenal tumors in the ENNG + 5% ALOE group were significantly decreased compared with that in the ENNG alone group. These results indicated that ALOE, especially at 10% in the diet, inhibits ENNG-induced duodenal tumorigenesis in mice.

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