Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin

H. Akamatsu, I. Kurokawa, S. Nishijima, Y. Asada

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains. Propionibaclerium granidosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalDermatology
Volume185
Issue number1
DOIs
Publication statusPublished - 1992

All Science Journal Classification (ASJC) codes

  • Dermatology

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