Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin

H. Akamatsu; I. Kurokawa; S. Nishijima; Y. Asada

doi:10.1159/000247401

Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin

H. Akamatsu, I. Kurokawa, S. Nishijima, Y. Asada

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains. Propionibaclerium granidosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.

Original language	English
Pages (from-to)	41-43
Number of pages	3
Journal	Dermatology
Volume	185
Issue number	1
DOIs	https://doi.org/10.1159/000247401
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dermatology

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10.1159/000247401

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title = "Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin",

abstract = "The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains. Propionibaclerium granidosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.",

author = "H. Akamatsu and I. Kurokawa and S. Nishijima and Y. Asada",

year = "1992",

doi = "10.1159/000247401",

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T1 - Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin

AU - Akamatsu, H.

AU - Kurokawa, I.

AU - Nishijima, S.

AU - Asada, Y.

PY - 1992

Y1 - 1992

N2 - The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains. Propionibaclerium granidosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.

AB - The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains. Propionibaclerium granidosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.

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SN - 1018-8665

VL - 185

SP - 41

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JO - Dermatology

JF - Dermatology

IS - 1

ER -

Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin

Abstract

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