Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro

Jian Ping Yang, Jocelyn P. Merin, Tatsunori Nakano, Tetsuji Kato, Yukio Kitade, Takashi Okamoto

Research output: Contribution to journalArticlepeer-review

154 Citations (Scopus)

Abstract

Nuclear factor κB (NF-κB) is a transcription factor that is critical for the inducible expression of multiple cellular and viral genes. DNA binding activity is essential for its function. Here, we report that gold compounds, especially aurothioglucose (AuTG), have a strong inhibitory effect on NF-κB-DNA binding. Our finding also reveals that Zn2+ is a necessary component of NF-κB for its DNA binding activity and that gold ion can efficiently block NF-κB-DNA binding, presumably through oxidation of the cysteins associated with zinc. This redox mechanism may provide an explanation for the observed efficacy of gold compounds in the treatment of rheumatoid arthritis.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalFEBS Letters
Volume361
Issue number1
DOIs
Publication statusPublished - 13-03-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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