Inhibitors of the TGF-β superfamily and their clinical applications

K. Tsuchida, Y. Sunada, S. Noji, T. Murakami, A. Uezumi, M. Nakatani

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-β family, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalMini-Reviews in Medicinal Chemistry
Volume6
Issue number11
DOIs
Publication statusPublished - 01-11-2006

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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