Inhibitors of the TGF-β superfamily and their clinical applications

Kunihiro Tsuchida, Y. Sunada, S. Noji, T. Murakami, A. Uezumi, Masashi Nakatani

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-β family, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalMini-Reviews in Medicinal Chemistry
Volume6
Issue number11
DOIs
Publication statusPublished - 01-11-2006

Fingerprint

Transforming Growth Factors
Myostatin
Activins
Growth Inhibitors
Bone Morphogenetic Proteins
Blocking Antibodies
Muscular Dystrophies
Bone Remodeling
Tooth
Obesity
Monoclonal Antibodies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Tsuchida, Kunihiro ; Sunada, Y. ; Noji, S. ; Murakami, T. ; Uezumi, A. ; Nakatani, Masashi. / Inhibitors of the TGF-β superfamily and their clinical applications. In: Mini-Reviews in Medicinal Chemistry. 2006 ; Vol. 6, No. 11. pp. 1255-1261.
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Inhibitors of the TGF-β superfamily and their clinical applications. / Tsuchida, Kunihiro; Sunada, Y.; Noji, S.; Murakami, T.; Uezumi, A.; Nakatani, Masashi.

In: Mini-Reviews in Medicinal Chemistry, Vol. 6, No. 11, 01.11.2006, p. 1255-1261.

Research output: Contribution to journalReview article

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