Abstract
The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-β family, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 1255-1261 |
| Number of pages | 7 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 6 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 01-11-2006 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Cancer Research
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Inhibitors of the TGF-β superfamily and their clinical applications. / Tsuchida, K.; Sunada, Y.; Noji, S.; Murakami, T.; Uezumi, A.; Nakatani, M.
In: Mini-Reviews in Medicinal Chemistry, Vol. 6, No. 11, 01.11.2006, p. 1255-1261.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Inhibitors of the TGF-β superfamily and their clinical applications
AU - Tsuchida, K.
AU - Sunada, Y.
AU - Noji, S.
AU - Murakami, T.
AU - Uezumi, A.
AU - Nakatani, M.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-β family, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.
AB - The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-β family, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.
UR - http://www.scopus.com/inward/record.url?scp=33750736310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750736310&partnerID=8YFLogxK
U2 - 10.2174/138955706778742759
DO - 10.2174/138955706778742759
M3 - Review article
C2 - 17100637
AN - SCOPUS:33750736310
VL - 6
SP - 1255
EP - 1261
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
SN - 1389-5575
IS - 11
ER -