Inhibitory action of adenosine 3′,5′-monophosphate on phosphatidylinositol turnover: Difference in tissue response

Kozo Kaibuchi, Yoshimi Takai, Yasuhiro Ogawa, Shuji Kimura, Yasutomi Nishizuka, Toshikazu Nakamura, Akito Tomomura, Akira Ichihara

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

There appear to be considerable differences among tissues in the inhibitory action of adenosine 3′,5′-monophosphate (cyclic AMP) on phosphatidylinositol (PI) turnover induced by various extracellular signals. The present studies were on human peripheral lymphocytes and rat hepatocytes. In the lymphocyte system, cells are activated by phytohemagglutinin that induces PI turnover, and this PI turnover and cellular activation are profoundly blocked by dibutyryl cyclic AMP as well as by prostaglandin E1 which markedly increases cyclic AMP. In contrast, in the hepatocyte system, glycogenolysis is enhanced by α-agonists that induce PI turnover as well as by β-agonists and glucagon that increase cyclic AMP. In these cells the two classes of receptors appear to function independently, and PI turnover is not inhibited by cyclic AMP.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume104
Issue number1
DOIs
Publication statusPublished - 15-01-1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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