Inhibitory Effect of Gabexate Mesilate on Human Neutrophil Function

K. Mikawa, H. Akamatsu, N. Maekawa, K. Nishina, H. Obara, Y. Niwa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Neutrophils accumulated in the lung are thought to play a key role in the pathogenesis of adult respiratory distress syndrome and interstitial pneumonia following bone-marrow transplantation. The effects of gabexate mesilate on several aspects of human neutrophil function have been investigated. Gabexate mesilate significantly decreased both the generation of reactive oxygen species (O2 , H202, OH·) by neutrophils and neutrophil chemotaxis. In contrast, the drug did not affect the levels of reactive oxygen species generated by a cell-free reactive-oxygen-species generating system. Intracellular calcium concentrations in neutrophils stimulated by f-Met-Leu-Phe were decreased in the presence of gabexate mesilate. These data suggest that the reduction in reactive-oxygen-species production and neutrophil chemotaxis by gabexate mesilate may contribute to the effectiveness of the drug in adult respiratory distress syndrome and interstitial pneumonia after bone-marrow transplantation. The suppression of the increase in intracellular calcium concentration may at least be responsible for the inhibition of these neutrophil functions by gabexate mesilate.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalJournal of International Medical Research
Volume22
Issue number5
DOIs
Publication statusPublished - 09-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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