Abstract
Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
| Original language | English |
|---|---|
| Pages (from-to) | 191-192 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series |
| Issue number | 27 |
| Publication status | Published - 01-12-1992 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases. / Yamaguchi, T.; Izuta, S.; Suzuki, Motoshi; Yoshida, S.; Matsukage, A.; Saneyoshi, M.
In: Nucleic acids symposium series, No. 27, 01.12.1992, p. 191-192.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.
AU - Yamaguchi, T.
AU - Izuta, S.
AU - Suzuki, Motoshi
AU - Yoshida, S.
AU - Matsukage, A.
AU - Saneyoshi, M.
PY - 1992/12/1
Y1 - 1992/12/1
N2 - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
AB - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
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M3 - Article
SP - 191
EP - 192
JO - Nucleic acids symposium series
JF - Nucleic acids symposium series
SN - 0261-3166
IS - 27
ER -