Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

T. Yamaguchi, S. Izuta, Motoshi Suzuki, S. Yoshida, A. Matsukage, M. Saneyoshi

Research output: Contribution to journalArticle

Abstract

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

Original languageEnglish
Pages (from-to)191-192
Number of pages2
JournalNucleic acids symposium series
Issue number27
Publication statusPublished - 01-12-1992
Externally publishedYes

Fingerprint

RNA-Directed DNA Polymerase
DNA-Directed DNA Polymerase
Human immunodeficiency virus 1 reverse transcriptase
triphosphoric acid

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{bf9cc0e9ce8d4d4d93525251ac8dd05a,
title = "Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.",
abstract = "Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.",
author = "T. Yamaguchi and S. Izuta and Motoshi Suzuki and S. Yoshida and A. Matsukage and M. Saneyoshi",
year = "1992",
month = "12",
day = "1",
language = "English",
pages = "191--192",
journal = "Nucleic acids symposium series",
issn = "0261-3166",
publisher = "Information Retrieval",
number = "27",

}

Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases. / Yamaguchi, T.; Izuta, S.; Suzuki, Motoshi; Yoshida, S.; Matsukage, A.; Saneyoshi, M.

In: Nucleic acids symposium series, No. 27, 01.12.1992, p. 191-192.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.

AU - Yamaguchi, T.

AU - Izuta, S.

AU - Suzuki, Motoshi

AU - Yoshida, S.

AU - Matsukage, A.

AU - Saneyoshi, M.

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

AB - Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

UR - http://www.scopus.com/inward/record.url?scp=0027033749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027033749&partnerID=8YFLogxK

M3 - Article

SP - 191

EP - 192

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

SN - 0261-3166

IS - 27

ER -