Abstract
Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.
| Original language | English |
|---|---|
| Pages (from-to) | 191-192 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series |
| Issue number | 27 |
| Publication status | Published - 1992 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Medicine(all)
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Yamaguchi, T., Izuta, S., Suzuki, M., Yoshida, S., Matsukage, A., & Saneyoshi, M. (1992). Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases. Nucleic acids symposium series, (27), 191-192.