Inhibitory effects of low-dose aloe-emodin on the development of colorectal tumors in Min mice

Kan Shimpo, Takeshi Chihara, Takaaki Kaneko, Hidehiko Beppu, Kazumasa Wakamatsu, Masanori Shinzato, Jun Yukitake, Shigeru Sonoda

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Abstract

Aloe-emodin (AE), a natural anthraquinone compound, has been reported to exhibit anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. In the present study, we investigated the cancer chemopreventive effects of AE in an Apc-deficient Min mouse model. In the first experiment, male Min mice were fed a basal diet or diets containing 5 ppm AE and 10 ppm AE for 12 weeks. The dietary administration of 5 ppm AE significantly reduced the number of colorectal tumors. In a second experiment, we investigated the effects of AE on colitis-related colon carcinogenesis in Min mouse treated with dextran sodium sulfate (DSS). Female Min mice were administered 1% DSS in their drinking water for 7 days. AE was given to mice in their diet at a dose of 5 or 50 ppm for 5 weeks. Feeding with AE significantly reduced the number of colorectal tumors. When proliferation of cells in normal-appearing colonic mucosa was assessed by monoclonal anti-rat Ki-67 antibody (MIB-5) immunohistochemistry in experiments 1 and 2, the AE treatment significantly decreased the mean MIB-5-labeling index. These results suggest that the dietary administration of low-dose AE may have chemopreventive effects against development of colorectal tumors in Min mice, possibly in part by reducing cell proliferation in colorectal mucosa.

Original languageEnglish
Pages (from-to)5587-5592
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number14
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Shimpo, K., Chihara, T., Kaneko, T., Beppu, H., Wakamatsu, K., Shinzato, M., Yukitake, J., & Sonoda, S. (2014). Inhibitory effects of low-dose aloe-emodin on the development of colorectal tumors in Min mice. Asian Pacific Journal of Cancer Prevention, 15(14), 5587-5592. https://doi.org/10.7314/APJCP.2014.15.14.5587