Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids

Y. Maeda, K. Yamada, T. Hasegawa, M. Iyo, S. Fukui, Toshitaka Nabeshima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was O.lIU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalJournal of Neural Transmission
Volume96
Issue number2
DOIs
Publication statusPublished - 01-06-1994

Fingerprint

salmon calcitonin
Excitatory Amino Acids
Substance P
Quisqualic Acid
Cerebral Ventricles
Kainic Acid
N-Methylaspartate
Excitatory Amino Acid Agonists
Neurokinin-1 Receptors
Spinal Injections
Glutamate Receptors

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

@article{21eaa65bd1e149f1b271945a70018a3e,
title = "Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids",
abstract = "We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was O.lIU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9{\%}, 40.2{\%}, 49.4{\%}, and 52.9{\%}, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.",
author = "Y. Maeda and K. Yamada and T. Hasegawa and M. Iyo and S. Fukui and Toshitaka Nabeshima",
year = "1994",
month = "6",
day = "1",
doi = "10.1007/BF01277934",
language = "English",
volume = "96",
pages = "125--133",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "2",

}

Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids. / Maeda, Y.; Yamada, K.; Hasegawa, T.; Iyo, M.; Fukui, S.; Nabeshima, Toshitaka.

In: Journal of Neural Transmission, Vol. 96, No. 2, 01.06.1994, p. 125-133.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids

AU - Maeda, Y.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Iyo, M.

AU - Fukui, S.

AU - Nabeshima, Toshitaka

PY - 1994/6/1

Y1 - 1994/6/1

N2 - We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was O.lIU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.

AB - We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was O.lIU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0028176778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028176778&partnerID=8YFLogxK

U2 - 10.1007/BF01277934

DO - 10.1007/BF01277934

M3 - Article

C2 - 7531982

AN - SCOPUS:0028176778

VL - 96

SP - 125

EP - 133

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 2

ER -