Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families

Tadao Arinami, H. Ishiguro, Y. Minowa, T. Ohtsuki, T. Tsujita, A. Imamura, T. Yoshikawa, T. Toyota, K. Yamada, H. Shimizu, K. Yoshitsugu, H. Shibata, Y. Fujii, Y. Fukumaki, N. Tashiro, T. Inada, Y. Iijima, Y. Kitao, T. Furuno, T. SomeyaT. Muratake, N. Kaneko, S. Tsuji, M. Mineta, M. Takeichi, H. Ujike, Y. Takehisa, Y. Tanaka, K. Nakata, Tsuyoshi Kitajima, T. Nishiyama, Y. Yamanouchi, Nakao Iwata, N. Ozaki, K. Ohara, H. Shibuya, Y. Suzuki, O. Ohmori, T. Shinkai, H. Hori, J. Nakamura, T. Kojima, S. Takahashi, E. Tanabe, K. Yara, S. Nanko, H. Yoneda, J. Koh, J. Sakai, Y. Inada, I. Kusumi, K. Kameda, T. Koyama, H. Fukuzako, T. Hashiguchi, K. Tanabe, Y. Okazaki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To determine if there are common genes that contribute to the susceptibility for schizophrenia, first-stage genome-wide scan was carried out by genotyping 417 short-tandem repeat (STR) markers in 338 individuals from 130 families with 148 affected sib-pairs identified at 16 sites nationwide in Japan. Data was from the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG), which is a multi-site collaborative study group established to create a national resource for genetic studies of schizophrenia in Japan. All subjects were Japanese, and the probands and their siblings had schizophrenia. Multipoint non-parametric linkage analysis and exclusion mapping were performed with GENEHUNTER software. Simulation studies suggested that in the absence of linkage we could expect one multipoint maximum LOD score (MLS) of 1.9 per genome scan. An MLS of 3.7 would be expected only once in every 20 genome scans and thus corresponds to a genome-wide significance of 0.05. No loci in the initial screen fulfilled the criteria for significant or suggestive evidence for linkage. Ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal P value < 0.05. Susceptibility genes with λs of 3 and 2 were excluded from 98 and 70% of the genome, respectively. Our results suggest that common genes that contribute significantly to susceptibility for schizophrenia are unlikely to exist in the Japanese population.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume120 B
Issue number1
Publication statusPublished - 01-07-2003

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Schizophrenia
Genome
Japan
Genes
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Microsatellite Repeats
Software
Population

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Arinami, Tadao ; Ishiguro, H. ; Minowa, Y. ; Ohtsuki, T. ; Tsujita, T. ; Imamura, A. ; Yoshikawa, T. ; Toyota, T. ; Yamada, K. ; Shimizu, H. ; Yoshitsugu, K. ; Shibata, H. ; Fujii, Y. ; Fukumaki, Y. ; Tashiro, N. ; Inada, T. ; Iijima, Y. ; Kitao, Y. ; Furuno, T. ; Someya, T. ; Muratake, T. ; Kaneko, N. ; Tsuji, S. ; Mineta, M. ; Takeichi, M. ; Ujike, H. ; Takehisa, Y. ; Tanaka, Y. ; Nakata, K. ; Kitajima, Tsuyoshi ; Nishiyama, T. ; Yamanouchi, Y. ; Iwata, Nakao ; Ozaki, N. ; Ohara, K. ; Shibuya, H. ; Suzuki, Y. ; Ohmori, O. ; Shinkai, T. ; Hori, H. ; Nakamura, J. ; Kojima, T. ; Takahashi, S. ; Tanabe, E. ; Yara, K. ; Nanko, S. ; Yoneda, H. ; Koh, J. ; Sakai, J. ; Inada, Y. ; Kusumi, I. ; Kameda, K. ; Koyama, T. ; Fukuzako, H. ; Hashiguchi, T. ; Tanabe, K. ; Okazaki, Y. / Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2003 ; Vol. 120 B, No. 1. pp. 22-28.
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abstract = "To determine if there are common genes that contribute to the susceptibility for schizophrenia, first-stage genome-wide scan was carried out by genotyping 417 short-tandem repeat (STR) markers in 338 individuals from 130 families with 148 affected sib-pairs identified at 16 sites nationwide in Japan. Data was from the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG), which is a multi-site collaborative study group established to create a national resource for genetic studies of schizophrenia in Japan. All subjects were Japanese, and the probands and their siblings had schizophrenia. Multipoint non-parametric linkage analysis and exclusion mapping were performed with GENEHUNTER software. Simulation studies suggested that in the absence of linkage we could expect one multipoint maximum LOD score (MLS) of 1.9 per genome scan. An MLS of 3.7 would be expected only once in every 20 genome scans and thus corresponds to a genome-wide significance of 0.05. No loci in the initial screen fulfilled the criteria for significant or suggestive evidence for linkage. Ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal P value < 0.05. Susceptibility genes with λs of 3 and 2 were excluded from 98 and 70{\%} of the genome, respectively. Our results suggest that common genes that contribute significantly to susceptibility for schizophrenia are unlikely to exist in the Japanese population.",
author = "Tadao Arinami and H. Ishiguro and Y. Minowa and T. Ohtsuki and T. Tsujita and A. Imamura and T. Yoshikawa and T. Toyota and K. Yamada and H. Shimizu and K. Yoshitsugu and H. Shibata and Y. Fujii and Y. Fukumaki and N. Tashiro and T. Inada and Y. Iijima and Y. Kitao and T. Furuno and T. Someya and T. Muratake and N. Kaneko and S. Tsuji and M. Mineta and M. Takeichi and H. Ujike and Y. Takehisa and Y. Tanaka and K. Nakata and Tsuyoshi Kitajima and T. Nishiyama and Y. Yamanouchi and Nakao Iwata and N. Ozaki and K. Ohara and H. Shibuya and Y. Suzuki and O. Ohmori and T. Shinkai and H. Hori and J. Nakamura and T. Kojima and S. Takahashi and E. Tanabe and K. Yara and S. Nanko and H. Yoneda and J. Koh and J. Sakai and Y. Inada and I. Kusumi and K. Kameda and T. Koyama and H. Fukuzako and T. Hashiguchi and K. Tanabe and Y. Okazaki",
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Arinami, T, Ishiguro, H, Minowa, Y, Ohtsuki, T, Tsujita, T, Imamura, A, Yoshikawa, T, Toyota, T, Yamada, K, Shimizu, H, Yoshitsugu, K, Shibata, H, Fujii, Y, Fukumaki, Y, Tashiro, N, Inada, T, Iijima, Y, Kitao, Y, Furuno, T, Someya, T, Muratake, T, Kaneko, N, Tsuji, S, Mineta, M, Takeichi, M, Ujike, H, Takehisa, Y, Tanaka, Y, Nakata, K, Kitajima, T, Nishiyama, T, Yamanouchi, Y, Iwata, N, Ozaki, N, Ohara, K, Shibuya, H, Suzuki, Y, Ohmori, O, Shinkai, T, Hori, H, Nakamura, J, Kojima, T, Takahashi, S, Tanabe, E, Yara, K, Nanko, S, Yoneda, H, Koh, J, Sakai, J, Inada, Y, Kusumi, I, Kameda, K, Koyama, T, Fukuzako, H, Hashiguchi, T, Tanabe, K & Okazaki, Y 2003, 'Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 120 B, no. 1, pp. 22-28.

Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families. / Arinami, Tadao; Ishiguro, H.; Minowa, Y.; Ohtsuki, T.; Tsujita, T.; Imamura, A.; Yoshikawa, T.; Toyota, T.; Yamada, K.; Shimizu, H.; Yoshitsugu, K.; Shibata, H.; Fujii, Y.; Fukumaki, Y.; Tashiro, N.; Inada, T.; Iijima, Y.; Kitao, Y.; Furuno, T.; Someya, T.; Muratake, T.; Kaneko, N.; Tsuji, S.; Mineta, M.; Takeichi, M.; Ujike, H.; Takehisa, Y.; Tanaka, Y.; Nakata, K.; Kitajima, Tsuyoshi; Nishiyama, T.; Yamanouchi, Y.; Iwata, Nakao; Ozaki, N.; Ohara, K.; Shibuya, H.; Suzuki, Y.; Ohmori, O.; Shinkai, T.; Hori, H.; Nakamura, J.; Kojima, T.; Takahashi, S.; Tanabe, E.; Yara, K.; Nanko, S.; Yoneda, H.; Koh, J.; Sakai, J.; Inada, Y.; Kusumi, I.; Kameda, K.; Koyama, T.; Fukuzako, H.; Hashiguchi, T.; Tanabe, K.; Okazaki, Y.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 120 B, No. 1, 01.07.2003, p. 22-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families

AU - Arinami, Tadao

AU - Ishiguro, H.

AU - Minowa, Y.

AU - Ohtsuki, T.

AU - Tsujita, T.

AU - Imamura, A.

AU - Yoshikawa, T.

AU - Toyota, T.

AU - Yamada, K.

AU - Shimizu, H.

AU - Yoshitsugu, K.

AU - Shibata, H.

AU - Fujii, Y.

AU - Fukumaki, Y.

AU - Tashiro, N.

AU - Inada, T.

AU - Iijima, Y.

AU - Kitao, Y.

AU - Furuno, T.

AU - Someya, T.

AU - Muratake, T.

AU - Kaneko, N.

AU - Tsuji, S.

AU - Mineta, M.

AU - Takeichi, M.

AU - Ujike, H.

AU - Takehisa, Y.

AU - Tanaka, Y.

AU - Nakata, K.

AU - Kitajima, Tsuyoshi

AU - Nishiyama, T.

AU - Yamanouchi, Y.

AU - Iwata, Nakao

AU - Ozaki, N.

AU - Ohara, K.

AU - Shibuya, H.

AU - Suzuki, Y.

AU - Ohmori, O.

AU - Shinkai, T.

AU - Hori, H.

AU - Nakamura, J.

AU - Kojima, T.

AU - Takahashi, S.

AU - Tanabe, E.

AU - Yara, K.

AU - Nanko, S.

AU - Yoneda, H.

AU - Koh, J.

AU - Sakai, J.

AU - Inada, Y.

AU - Kusumi, I.

AU - Kameda, K.

AU - Koyama, T.

AU - Fukuzako, H.

AU - Hashiguchi, T.

AU - Tanabe, K.

AU - Okazaki, Y.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - To determine if there are common genes that contribute to the susceptibility for schizophrenia, first-stage genome-wide scan was carried out by genotyping 417 short-tandem repeat (STR) markers in 338 individuals from 130 families with 148 affected sib-pairs identified at 16 sites nationwide in Japan. Data was from the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG), which is a multi-site collaborative study group established to create a national resource for genetic studies of schizophrenia in Japan. All subjects were Japanese, and the probands and their siblings had schizophrenia. Multipoint non-parametric linkage analysis and exclusion mapping were performed with GENEHUNTER software. Simulation studies suggested that in the absence of linkage we could expect one multipoint maximum LOD score (MLS) of 1.9 per genome scan. An MLS of 3.7 would be expected only once in every 20 genome scans and thus corresponds to a genome-wide significance of 0.05. No loci in the initial screen fulfilled the criteria for significant or suggestive evidence for linkage. Ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal P value < 0.05. Susceptibility genes with λs of 3 and 2 were excluded from 98 and 70% of the genome, respectively. Our results suggest that common genes that contribute significantly to susceptibility for schizophrenia are unlikely to exist in the Japanese population.

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JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

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SN - 1552-4841

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