Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Hiroyuki Mizoguchi, Kentaro Katahira, Ayumu Inutsuka, Kazuya Fukumoto, Akihiro Nakamura, Tian Wang, Taku Nagai, Jun Sato, Makoto Sawada, Hideki Ohira, Akihiro Yamanaka, Kiyofumi Yamada

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24 Citations (Scopus)

Abstract

Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.

Original languageEnglish
Pages (from-to)E3930-E3939
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number29
DOIs
Publication statusPublished - 21-07-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

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    Mizoguchi, H., Katahira, K., Inutsuka, A., Fukumoto, K., Nakamura, A., Wang, T., Nagai, T., Sato, J., Sawada, M., Ohira, H., Yamanaka, A., & Yamada, K. (2015). Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Proceedings of the National Academy of Sciences of the United States of America, 112(29), E3930-E3939. https://doi.org/10.1073/pnas.1418014112