Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma

Yasunaga Ono, Naohisa Oda, Shin Ishihara, Atsushi Shimomura, Nobuki Hayakawa, Atsushi Suzuki, Akihiko Horiguchi, Takao Senda, Shuichi Miyakawa, Mitsuyasu Itoh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Context and objective: Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin secretion remains unclear. Both insulinoma and familial hypocalciuric hypercalcemia (FHH) are rare diseases. This study reports on a case in which both of these diseases occur concurrently. Design and patient: The patient with FHH also suffered from insulinoma. We reasoned that insulin secretion for ASVS is dependent on the calcium-sensing receptor (CaSR). ASVS was performed on this patient. The expression of the CaSR protein and corresponding mRNA were confirmed. Results: No significant changes in the plasma levels of insulin and C-peptide were observed during ASVS. The patient was clinically diagnosed as having FHH. We confirmed that a mutation in the CaSR gene was present in the genomic DNA of this patient and that there were no mutations in the multiple endocrine neoplasia type 1 gene. In addition, expression of both CaSR mRNA and CaSR protein was confirmed in the insulinoma samples. Conclusion: These results suggest that the CaSR gene is involved in ASVS-induced insulin secretion.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalEuropean Journal of Endocrinology
Volume159
Issue number1
DOIs
Publication statusPublished - 01-07-2008

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Calcium-Sensing Receptors
Insulinoma
Insulin
Genes
Multiple Endocrine Neoplasia Type 1
Messenger RNA
Mutation
C-Peptide
Rare Diseases
Hypocalciuric hypercalcemia, familial, type 1
Arteries
Calcium
Injections
DNA

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Ono, Yasunaga ; Oda, Naohisa ; Ishihara, Shin ; Shimomura, Atsushi ; Hayakawa, Nobuki ; Suzuki, Atsushi ; Horiguchi, Akihiko ; Senda, Takao ; Miyakawa, Shuichi ; Itoh, Mitsuyasu. / Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma. In: European Journal of Endocrinology. 2008 ; Vol. 159, No. 1. pp. 81-86.
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Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma. / Ono, Yasunaga; Oda, Naohisa; Ishihara, Shin; Shimomura, Atsushi; Hayakawa, Nobuki; Suzuki, Atsushi; Horiguchi, Akihiko; Senda, Takao; Miyakawa, Shuichi; Itoh, Mitsuyasu.

In: European Journal of Endocrinology, Vol. 159, No. 1, 01.07.2008, p. 81-86.

Research output: Contribution to journalArticle

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AU - Ono, Yasunaga

AU - Oda, Naohisa

AU - Ishihara, Shin

AU - Shimomura, Atsushi

AU - Hayakawa, Nobuki

AU - Suzuki, Atsushi

AU - Horiguchi, Akihiko

AU - Senda, Takao

AU - Miyakawa, Shuichi

AU - Itoh, Mitsuyasu

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