Intake frequency of fish and serum levels of long-chain n-3 fatty acids: A cross-sectional study within the Japan Collaborative Cohort Study

Kenji Wakai, Yoshinori Ito, Masayo Kojima, Shinkan Tokudome, Kotaro Ozasa, Yutaka Inaba, Kiyoko Yagyu, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuhi, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shuji Hashimoto, Shogo KikuchiAkio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tahjima

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. Methods: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. Results: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosa-hexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0. 11 to 0. 18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7% to 40%. Conclusions: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalJournal of epidemiology
Volume15
Issue number6
DOIs
Publication statusPublished - 07-11-2005

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Omega-3 Fatty Acids
Japan
Fishes
Cohort Studies
Cross-Sectional Studies
Serum
Fatty Acids
Gas Chromatography
Biological Availability
Case-Control Studies
Fasting
Weights and Measures
Acids

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Wakai, Kenji ; Ito, Yoshinori ; Kojima, Masayo ; Tokudome, Shinkan ; Ozasa, Kotaro ; Inaba, Yutaka ; Yagyu, Kiyoko ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuhi, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tahjima, Kazuo. / Intake frequency of fish and serum levels of long-chain n-3 fatty acids : A cross-sectional study within the Japan Collaborative Cohort Study. In: Journal of epidemiology. 2005 ; Vol. 15, No. 6. pp. 211-218.
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abstract = "Background: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. Methods: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. Results: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosa-hexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0. 11 to 0. 18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7{\%} to 40{\%}. Conclusions: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.",
author = "Kenji Wakai and Yoshinori Ito and Masayo Kojima and Shinkan Tokudome and Kotaro Ozasa and Yutaka Inaba and Kiyoko Yagyu and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuhi and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tahjima",
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Wakai, K, Ito, Y, Kojima, M, Tokudome, S, Ozasa, K, Inaba, Y, Yagyu, K, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuhi, I, Nakamura, Y, Iso, H, Mikami, H, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tahjima, K 2005, 'Intake frequency of fish and serum levels of long-chain n-3 fatty acids: A cross-sectional study within the Japan Collaborative Cohort Study', Journal of epidemiology, vol. 15, no. 6, pp. 211-218. https://doi.org/10.2188/jea.15.211

Intake frequency of fish and serum levels of long-chain n-3 fatty acids : A cross-sectional study within the Japan Collaborative Cohort Study. / Wakai, Kenji; Ito, Yoshinori; Kojima, Masayo; Tokudome, Shinkan; Ozasa, Kotaro; Inaba, Yutaka; Yagyu, Kiyoko; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuhi, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tahjima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. 6, 07.11.2005, p. 211-218.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intake frequency of fish and serum levels of long-chain n-3 fatty acids

T2 - A cross-sectional study within the Japan Collaborative Cohort Study

AU - Wakai, Kenji

AU - Ito, Yoshinori

AU - Kojima, Masayo

AU - Tokudome, Shinkan

AU - Ozasa, Kotaro

AU - Inaba, Yutaka

AU - Yagyu, Kiyoko

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuhi, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tahjima, Kazuo

PY - 2005/11/7

Y1 - 2005/11/7

N2 - Background: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. Methods: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. Results: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosa-hexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0. 11 to 0. 18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7% to 40%. Conclusions: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.

AB - Background: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. Methods: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. Results: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosa-hexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0. 11 to 0. 18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7% to 40%. Conclusions: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.

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DO - 10.2188/jea.15.211

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