Intake frequency of fish and serum levels of long-chain n-3 fatty acids: A cross-sectional study within the Japan Collaborative Cohort Study

Kenji Wakai, Yoshinori Ito, Masayo Kojima, Shinkan Tokudome, Kotaro Ozasa, Yutaka Inaba, Kiyoko Yagyu, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuhi, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shuji Hashimoto, Shogo KikuchiAkio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tahjima

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Abstract

Background: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. Methods: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. Results: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosa-hexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0. 11 to 0. 18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7% to 40%. Conclusions: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalJournal of epidemiology
Volume15
Issue number6
DOIs
Publication statusPublished - 07-11-2005

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Wakai, K., Ito, Y., Kojima, M., Tokudome, S., Ozasa, K., Inaba, Y., Yagyu, K., Tamakoshi, A., Mori, M., Motohashi, Y., Tsuhi, I., Nakamura, Y., Iso, H., Mikami, H., Hoshiyama, Y., Suzuki, H., Shimizu, H., Toyoshima, H., Hashimoto, S., ... Tahjima, K. (2005). Intake frequency of fish and serum levels of long-chain n-3 fatty acids: A cross-sectional study within the Japan Collaborative Cohort Study. Journal of epidemiology, 15(6), 211-218. https://doi.org/10.2188/jea.15.211