Integrated approach toward the discovery of glyco-biomarkers of inflammation-Related diseases

Takashi Angata, Reiko Fujinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume, Naoyuki Taniguchi

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Glycobiology has contributed tremendously to the discovery and characterization of cancer-related biomarkers containing glycans (i.e., glyco-biomarkers) and a more detailed understanding of cancer biology. It is now recognized that most chronic diseases involve some elements of chronic inflammation; these include cancer, Alzheimer's disease, and metabolic syndrome (including consequential diabetes mellitus and cardiovascular diseases). By extending the knowledge and experience of the glycobiology community regarding cancer biomarker discovery, we should be able to contribute to the discovery of diagnostic/prognostic glyco-biomarkers of other chronic diseases that involve chronic inflammation. Future integration of large-scale "omics"-type data (e.g., genomics, epigenomics, transcriptomics, proteomics, and glycomics) with computational model building, or a systems glycobiology approach, will facilitate such efforts.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1253
Issue number1
DOIs
Publication statusPublished - 01-01-2012

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Glycomics
Biomarkers
Inflammation
Tumor Biomarkers
Chronic Disease
Medical problems
Genomics
Epigenomics
Proteomics
Polysaccharides
Neoplasms
Diabetes Mellitus
Alzheimer Disease
Cardiovascular Diseases
Cancer

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Angata, Takashi ; Fujinawa, Reiko ; Kurimoto, Ayako ; Nakajima, Kazuki ; Kato, Masaki ; Takamatsu, Shinji ; Korekane, Hiroaki ; Gao, Cong Xiao ; Ohtsubo, Kazuaki ; Kitazume, Shinobu ; Taniguchi, Naoyuki. / Integrated approach toward the discovery of glyco-biomarkers of inflammation-Related diseases. In: Annals of the New York Academy of Sciences. 2012 ; Vol. 1253, No. 1. pp. 159-169.
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Angata, T, Fujinawa, R, Kurimoto, A, Nakajima, K, Kato, M, Takamatsu, S, Korekane, H, Gao, CX, Ohtsubo, K, Kitazume, S & Taniguchi, N 2012, 'Integrated approach toward the discovery of glyco-biomarkers of inflammation-Related diseases', Annals of the New York Academy of Sciences, vol. 1253, no. 1, pp. 159-169. https://doi.org/10.1111/j.1749-6632.2012.06469.x

Integrated approach toward the discovery of glyco-biomarkers of inflammation-Related diseases. / Angata, Takashi; Fujinawa, Reiko; Kurimoto, Ayako; Nakajima, Kazuki; Kato, Masaki; Takamatsu, Shinji; Korekane, Hiroaki; Gao, Cong Xiao; Ohtsubo, Kazuaki; Kitazume, Shinobu; Taniguchi, Naoyuki.

In: Annals of the New York Academy of Sciences, Vol. 1253, No. 1, 01.01.2012, p. 159-169.

Research output: Contribution to journalReview article

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AU - Kurimoto, Ayako

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AU - Kato, Masaki

AU - Takamatsu, Shinji

AU - Korekane, Hiroaki

AU - Gao, Cong Xiao

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AU - Kitazume, Shinobu

AU - Taniguchi, Naoyuki

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