Integrin activation and matrix binding mediate cellular responses to mechanical stretch

Akira Katsumi, Tomoki Naoe, Tadashi Matsushita, Kozo Kaibuchi, Martin Alexander Schwartz

Research output: Contribution to journalArticlepeer-review

178 Citations (Scopus)

Abstract

Mechanical tension is a critical determinant of cell growth, differentiation, apoptosis, migration, and development. Integrins have been implicated in sensing force but little is known about how forces are transduced to biochemical signals. We now show that mechanical strain stimulates conformational activation of integrin αvβ3 in NIH3T3 cells. Integrin activation is mediated by phosphoinositol 3-kinase and is followed by an increase in integrin binding to extracellular matrix proteins. Mechanical stretch stimulation of JNK was dependent on new integrin binding to extracellular matrix. These data define a molecular mechanism for the role of integrins in mechanotransduction.

Original languageEnglish
Pages (from-to)16546-16549
Number of pages4
JournalJournal of Biological Chemistry
Volume280
Issue number17
DOIs
Publication statusPublished - 29-04-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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