Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda, Naoki Horikoshi, Takayuki Murata, Daisuke Kawashima, Atsuko Sugimoto, Yohei Narita, Hitoshi Kurumizaka, Tatsuya Tsurumi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

Original languageEnglish
Pages (from-to)24189-24199
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
Publication statusPublished - 16-08-2013

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Chromosomes
Human Herpesvirus 4
Viruses
Chromatin
Plasmids
Maintenance
Proteins
Lysine
Arginine
Acoustic waves
Learning

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kanda, Teru ; Horikoshi, Naoki ; Murata, Takayuki ; Kawashima, Daisuke ; Sugimoto, Atsuko ; Narita, Yohei ; Kurumizaka, Hitoshi ; Tsurumi, Tatsuya. / Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 33. pp. 24189-24199.
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Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance. / Kanda, Teru; Horikoshi, Naoki; Murata, Takayuki; Kawashima, Daisuke; Sugimoto, Atsuko; Narita, Yohei; Kurumizaka, Hitoshi; Tsurumi, Tatsuya.

In: Journal of Biological Chemistry, Vol. 288, No. 33, 16.08.2013, p. 24189-24199.

Research output: Contribution to journalArticle

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AU - Narita, Yohei

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