Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda; Naoki Horikoshi; Takayuki Murata; Daisuke Kawashima; Atsuko Sugimoto; Yohei Narita; Hitoshi Kurumizaka; Tatsuya Tsurumi

doi:10.1074/jbc.M113.491167

Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda, Naoki Horikoshi, Takayuki Murata, Daisuke Kawashima, Atsuko Sugimoto, Yohei Narita, Hitoshi Kurumizaka, Tatsuya Tsurumi

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

Original language	English
Pages (from-to)	24189-24199
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.491167
Publication status	Published - 16-08-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.491167

Cite this

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abstract = "Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.",

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T1 - Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

AU - Kanda, Teru

AU - Horikoshi, Naoki

AU - Murata, Takayuki

AU - Kawashima, Daisuke

AU - Sugimoto, Atsuko

AU - Narita, Yohei

AU - Kurumizaka, Hitoshi

AU - Tsurumi, Tatsuya

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

AB - Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

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DO - 10.1074/jbc.M113.491167

M3 - Article

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EP - 24199

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 33

ER -

Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Abstract

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