Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory

Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalDrug News and Perspectives
Volume17
Issue number7
DOIs
Publication statusPublished - 01-09-2004
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
N-Methyl-D-Aspartate Receptors
Learning
Phosphatidylinositol 3-Kinase
trkB Receptor
Episodic Memory
src-Family Kinases
Mitogens
Protein Kinases
Single Nucleotide Polymorphism
Messenger RNA
Brain
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

@article{458fa423822346388eb28d08dd20500a,
title = "Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory",
abstract = "Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.",
author = "Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2004",
month = "9",
day = "1",
doi = "10.1358/dnp.2004.17.7.863702",
language = "English",
volume = "17",
pages = "435--438",
journal = "Drug News and Perspectives",
issn = "0214-0934",
publisher = "Prous Science",
number = "7",

}

Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory. / Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Drug News and Perspectives, Vol. 17, No. 7, 01.09.2004, p. 435-438.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.

AB - Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.

UR - http://www.scopus.com/inward/record.url?scp=6344287131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6344287131&partnerID=8YFLogxK

U2 - 10.1358/dnp.2004.17.7.863702

DO - 10.1358/dnp.2004.17.7.863702

M3 - Review article

VL - 17

SP - 435

EP - 438

JO - Drug News and Perspectives

JF - Drug News and Perspectives

SN - 0214-0934

IS - 7

ER -