Abstract
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.
| Original language | English |
|---|---|
| Pages (from-to) | 435-438 |
| Number of pages | 4 |
| Journal | Drug News and Perspectives |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 01-09-2004 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
Cite this
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Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory. / Yamada, Kiyofumi; Nabeshima, Toshitaka.
In: Drug News and Perspectives, Vol. 17, No. 7, 01.09.2004, p. 435-438.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Interaction of BDNF/TrkB signaling with NMDA receptors in learning and memory
AU - Yamada, Kiyofumi
AU - Nabeshima, Toshitaka
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.
AB - Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play important roles in learning and memory. Memory acquisition is associated with an increase in BDNF mRNA and TrkB activation in specific brain areas. Pharmacologic and genetic deprivation of BDNF or TrkB results in an impairment of memory. Activation of the mitogen-associated protein kinase and phosphatidylinositol 3-kinase signaling pathways is involved in BDNF-dependent learning and memory. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) is associated with poorer episodic memory and abnormal hippocampal neuronal function in humans. The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B.
UR - http://www.scopus.com/inward/record.url?scp=6344287131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6344287131&partnerID=8YFLogxK
U2 - 10.1358/dnp.2004.17.7.863702
DO - 10.1358/dnp.2004.17.7.863702
M3 - Review article
C2 - 15514702
AN - SCOPUS:6344287131
VL - 17
SP - 435
EP - 438
JO - Drug News and Perspectives
JF - Drug News and Perspectives
SN - 0214-0934
IS - 7
ER -