Interactions of endotoxin with cortisol and acute phase proteins in septic shock neonates

H. Togari, S. Sugiyama, T. Ogino, S. Suzuki, T. Ito, T. Ichiki, K. Kamiya, I. Watanabe, Y. Ogawa, Y. Wada

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Abstract

CRP, α1-acid glycoprotein and haptoglobin were studied in 13 septic shock neonates. Endotoxin was recovered from eight infants. Serum cortisol concentration from infants with endotoxemia (917 ± 596 ng/ml) was significantly higher than that from infants without endotoxemia (398 ± 239 ng/ml). Serum cortisol correlated well with immature neutrophil counts preceded the elevation of CRP, α1-acid glycoprotein and haptoglobin in four extremely premature neonates. We conclude that positive interactions between endotoxin, cortisol and acute phase protein synthesis are present in the initial period of infection, and delayed acute phase protein synthesis is suspected in extremely premature neonates.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalActa Paediatrica Scandinavica
Volume75
Issue number1
Publication statusPublished - 11-06-1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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    Togari, H., Sugiyama, S., Ogino, T., Suzuki, S., Ito, T., Ichiki, T., Kamiya, K., Watanabe, I., Ogawa, Y., & Wada, Y. (1986). Interactions of endotoxin with cortisol and acute phase proteins in septic shock neonates. Acta Paediatrica Scandinavica, 75(1), 69-74.