TY - JOUR
T1 - Interactions of endotoxin with cortisol and acute phase proteins in septic shock neonates
AU - Togari, H.
AU - Sugiyama, S.
AU - Ogino, T.
AU - Suzuki, S.
AU - Ito, T.
AU - Ichiki, T.
AU - Kamiya, K.
AU - Watanabe, I.
AU - Ogawa, Y.
AU - Wada, Y.
PY - 1986
Y1 - 1986
N2 - CRP, α1-acid glycoprotein and haptoglobin were studied in 13 septic shock neonates. Endotoxin was recovered from eight infants. Serum cortisol concentration from infants with endotoxemia (917 ± 596 ng/ml) was significantly higher than that from infants without endotoxemia (398 ± 239 ng/ml). Serum cortisol correlated well with immature neutrophil counts preceded the elevation of CRP, α1-acid glycoprotein and haptoglobin in four extremely premature neonates. We conclude that positive interactions between endotoxin, cortisol and acute phase protein synthesis are present in the initial period of infection, and delayed acute phase protein synthesis is suspected in extremely premature neonates.
AB - CRP, α1-acid glycoprotein and haptoglobin were studied in 13 septic shock neonates. Endotoxin was recovered from eight infants. Serum cortisol concentration from infants with endotoxemia (917 ± 596 ng/ml) was significantly higher than that from infants without endotoxemia (398 ± 239 ng/ml). Serum cortisol correlated well with immature neutrophil counts preceded the elevation of CRP, α1-acid glycoprotein and haptoglobin in four extremely premature neonates. We conclude that positive interactions between endotoxin, cortisol and acute phase protein synthesis are present in the initial period of infection, and delayed acute phase protein synthesis is suspected in extremely premature neonates.
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U2 - 10.1111/j.1651-2227.1986.tb10159.x
DO - 10.1111/j.1651-2227.1986.tb10159.x
M3 - Article
C2 - 3953280
AN - SCOPUS:0022652499
SN - 0001-656X
VL - 75
SP - 69
EP - 74
JO - Acta Paediatrica Scandinavica
JF - Acta Paediatrica Scandinavica
IS - 1
ER -