Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

Isamu Mori; Tetsuo Koshizuka; Fumi Goshima; Hiroyasu Ito; Naoki Koide; Tomoaki Yoshida; Takashi Yokochi; Yoshinobu Kimura; Yukihiro Nishiyama

doi:10.1016/j.molbrainres.2005.02.004

Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

Isamu Mori, Tetsuo Koshizuka, Fumi Goshima, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

Anatomy and Medical Biology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.

Original language	English
Pages (from-to)	158-163
Number of pages	6
Journal	Molecular Brain Research
Volume	136
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molbrainres.2005.02.004
Publication status	Published - 20-05-2005

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/j.molbrainres.2005.02.004

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title = "Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain",

abstract = "The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.",

keywords = "Gene therapy, HSV, Human immunodeficiency virus, Infection, Intercellular trafficking, Neural stem cell, Neuron, Nucleus, Polyethylenimine, US11",

author = "Isamu Mori and Tetsuo Koshizuka and Fumi Goshima and Hiroyasu Ito and Naoki Koide and Tomoaki Yoshida and Takashi Yokochi and Yoshinobu Kimura and Yukihiro Nishiyama",

note = "Funding Information: We thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported in part by a Grant-in-Aid for Science Research of Japan Society of the Promotion of Science (JSPS) (15590424). I. Mori is the recipient of an Encouragement of Young Scientist Award (2003) from the Nakanihon Infectious Diseases Research Foundation, Japan.",

year = "2005",

month = may,

day = "20",

doi = "10.1016/j.molbrainres.2005.02.004",

language = "English",

volume = "136",

pages = "158--163",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier B.V.",

number = "1-2",

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TY - JOUR

T1 - Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

AU - Mori, Isamu

AU - Koshizuka, Tetsuo

AU - Goshima, Fumi

AU - Ito, Hiroyasu

AU - Koide, Naoki

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

AU - Kimura, Yoshinobu

AU - Nishiyama, Yukihiro

N1 - Funding Information: We thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported in part by a Grant-in-Aid for Science Research of Japan Society of the Promotion of Science (JSPS) (15590424). I. Mori is the recipient of an Encouragement of Young Scientist Award (2003) from the Nakanihon Infectious Diseases Research Foundation, Japan.

PY - 2005/5/20

Y1 - 2005/5/20

N2 - The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.

AB - The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.

KW - Gene therapy

KW - HSV

KW - Human immunodeficiency virus

KW - Infection

KW - Intercellular trafficking

KW - Neural stem cell

KW - Neuron

KW - Nucleus

KW - Polyethylenimine

KW - US11

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U2 - 10.1016/j.molbrainres.2005.02.004

DO - 10.1016/j.molbrainres.2005.02.004

M3 - Article

C2 - 15893600

AN - SCOPUS:18944377619

SN - 0169-328X

VL - 136

SP - 158

EP - 163

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

Abstract

All Science Journal Classification (ASJC) codes

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