TY - JOUR
T1 - Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain
AU - Mori, Isamu
AU - Koshizuka, Tetsuo
AU - Goshima, Fumi
AU - Ito, Hiroyasu
AU - Koide, Naoki
AU - Yoshida, Tomoaki
AU - Yokochi, Takashi
AU - Kimura, Yoshinobu
AU - Nishiyama, Yukihiro
N1 - Funding Information:
We thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported in part by a Grant-in-Aid for Science Research of Japan Society of the Promotion of Science (JSPS) (15590424). I. Mori is the recipient of an Encouragement of Young Scientist Award (2003) from the Nakanihon Infectious Diseases Research Foundation, Japan.
PY - 2005/5/20
Y1 - 2005/5/20
N2 - The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.
AB - The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.
UR - http://www.scopus.com/inward/record.url?scp=18944377619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18944377619&partnerID=8YFLogxK
U2 - 10.1016/j.molbrainres.2005.02.004
DO - 10.1016/j.molbrainres.2005.02.004
M3 - Article
C2 - 15893600
AN - SCOPUS:18944377619
VL - 136
SP - 158
EP - 163
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -