Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

Isamu Mori, Tetsuo Koshizuka, Fumi Goshima, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The US11 gene product of herpes simplex virus is an RNA-binding protein with a C-terminal arginine-X-proline (RXP) repeating motif. We found that the RXP repeat mediates intercellular trafficking activity and accumulation in neuronal nuclei following in vivo transfection with the US11 gene, direct injection of the purified RXP-repeat fusion protein, or infection with herpes simplex virus. We discuss a possible therapeutic application of the US11 protein RXP repeat as a tactic against neurodegenerative disorders of the central nervous system.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalMolecular Brain Research
Volume136
Issue number1-2
DOIs
Publication statusPublished - 20-05-2005

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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