Interethnic analyses of blood pressure loci in populations of East Asian and European descent

The International Genomics of Blood Pressure (iGEN-BP) Consortium

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Original languageEnglish
Article number5052
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

blood pressure
Blood pressure
descent
loci
Blood Pressure
Population
genome
Genetic Loci
diastolic pressure
Genes
Genetic Selection
Genome-Wide Association Study
linkages
Linkage Disequilibrium
Proxy
Ethnic Groups
Meta-Analysis
Cardiovascular Diseases
Genome

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

The International Genomics of Blood Pressure (iGEN-BP) Consortium. / Interethnic analyses of blood pressure loci in populations of East Asian and European descent. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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abstract = "Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.",
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Interethnic analyses of blood pressure loci in populations of East Asian and European descent. / The International Genomics of Blood Pressure (iGEN-BP) Consortium.

In: Nature Communications, Vol. 9, No. 1, 5052, 01.12.2018.

Research output: Contribution to journalArticle

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