Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian; Naoki Koide; Mya Mu Mya; Ferdaus Hassan; Shamima Islam; Tomoaki Yoshida; Takashi Yokochi

doi:10.1016/j.canlet.2004.11.054

Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian, Naoki Koide, Mya Mu Mya, Ferdaus Hassan, Shamima Islam, Tomoaki Yoshida, Takashi Yokochi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

Original language	English
Pages (from-to)	85-92
Number of pages	8
Journal	Cancer Letters
Volume	225
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.11.054
Publication status	Published - 08-07-2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.canlet.2004.11.054

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title = "Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)",

abstract = "The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.",

author = "Amaylia Oehadian and Naoki Koide and Mya, {Mya Mu} and Ferdaus Hassan and Shamima Islam and Tomoaki Yoshida and Takashi Yokochi",

note = "Funding Information: This work was partially supported by a Grant for Foreign Researcher from Aichi Medical University School of Medicine.",

year = "2005",

month = jul,

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doi = "10.1016/j.canlet.2004.11.054",

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journal = "Cancer Letters",

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Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). / Oehadian, Amaylia; Koide, Naoki; Mya, Mya Mu; Hassan, Ferdaus; Islam, Shamima; Yoshida, Tomoaki; Yokochi, Takashi.

In: Cancer Letters, Vol. 225, No. 1, 08.07.2005, p. 85-92.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

AU - Oehadian, Amaylia

AU - Koide, Naoki

AU - Mya, Mya Mu

AU - Hassan, Ferdaus

AU - Islam, Shamima

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

N1 - Funding Information: This work was partially supported by a Grant for Foreign Researcher from Aichi Medical University School of Medicine.

PY - 2005/7/8

Y1 - 2005/7/8

N2 - The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

AB - The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

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JF - Cancer Letters

SN - 0304-3835

IS - 1

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Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Abstract

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