Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian; Naoki Koide; Mya Mu Mya; Ferdaus Hassan; Shamima Islam; Tomoaki Yoshida; Takashi Yokochi

doi:10.1016/j.canlet.2004.11.054

Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Amaylia Oehadian
, Naoki Koide
, Mya Mu Mya
, Ferdaus Hassan
, Shamima Islam
, Tomoaki Yoshida
, Takashi Yokochi

Anatomy and Medical Biology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

Original language	English
Pages (from-to)	85-92
Number of pages	8
Journal	Cancer Letters
Volume	225
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.11.054
Publication status	Published - 08-07-2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1016/j.canlet.2004.11.054

Cite this

@article{9fc4e86cb2a44671a6cbe0ad8e75d8b5,

title = "Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)",

abstract = "The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.",

keywords = "Apoptosis, DHL-4 cells, Diffuse large B lymphoma, IFN-β, TRAIL",

author = "Amaylia Oehadian and Naoki Koide and Mya, \{Mya Mu\} and Ferdaus Hassan and Shamima Islam and Tomoaki Yoshida and Takashi Yokochi",

note = "Funding Information: This work was partially supported by a Grant for Foreign Researcher from Aichi Medical University School of Medicine.",

year = "2005",

month = jul,

day = "8",

doi = "10.1016/j.canlet.2004.11.054",

language = "English",

volume = "225",

pages = "85--92",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

AU - Oehadian, Amaylia

AU - Koide, Naoki

AU - Mya, Mya Mu

AU - Hassan, Ferdaus

AU - Islam, Shamima

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

N1 - Funding Information: This work was partially supported by a Grant for Foreign Researcher from Aichi Medical University School of Medicine.

PY - 2005/7/8

Y1 - 2005/7/8

N2 - The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

AB - The effect of interferon (IFN)-α, β and γ on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-β significantly inhibited the cell growth, and the effect was stronger than that of IFN-α. IFN-γ did not inhibit the cell growth because of lack of IFN-γ receptors. IFN-β caused apoptotic cell death which was accompanied by DNA fragmentation, caspase 3 activation and annexin V binding. IFN-β lead to the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA. Anti-TRAIL antibody significantly prevented IFN-β-induced apoptosis. It was suggested that IFN-β might cause apoptosis in DHL-4 cells through TRAIL.

KW - Apoptosis

KW - DHL-4 cells

KW - Diffuse large B lymphoma

KW - IFN-β

KW - TRAIL

UR - https://www.scopus.com/pages/publications/19544362348

UR - https://www.scopus.com/pages/publications/19544362348#tab=citedBy

U2 - 10.1016/j.canlet.2004.11.054

DO - 10.1016/j.canlet.2004.11.054

M3 - Article

C2 - 15922860

AN - SCOPUS:19544362348

SN - 0304-3835

VL - 225

SP - 85

EP - 92

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Interferon (IFN)-β induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this