Intestinal cancers occurring in patients with Crohn's disease

Toru Kamiya, Takafumi Ando, Kazuhiro Ishiguro, Osamu Maeda, Osamu Watanabe, Satoshi Hibi, Shunya Mimura, Masaki Ujihara, Yutaka Hirayama, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Hidemi Goto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and Aims: The number of patients with Crohn's disease (CD) and the number of cases of intestinal cancer associated with CD have both been increasing in Japan. However, the number of reported cases is lower than for ulcerative colitis-associated cancer. The aim of this study was to identify the clinical picture of CD-associated intestinal cancer in a consecutive series of patients with CD and to stress the importance of surveillance. Methods: We enrolled 174 consecutive patients (130 men, 44 women, mean age 25years) diagnosed with CD and investigated the development of intestinal cancer from October 1998 to July 2010. There were 104 cases of the ileocolitis type, 47 of ileitis, and 23 of colitis. Results: Intestinal cancer developed in two male patients (1.5% of the total), whose respective ages at onset of CD were 41 and 19years, and 55 and 37years at onset of cancer. Both cases were of ileocolitis-type CD; one cancer developed in the rectum and the other in the small bowel, and both were accompanied by severe stricture. Histopathological results revealed well and moderately differentiated adenocarcinoma, respectively. Conclusions: Intestinal cancer developed in patients with ileocolitis-type CD of more than 10years' duration. Our findings suggest that patients with chronic, widespread CD should be under cancer surveillance.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume27
Issue numberSUPPL.3
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

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Intestinal Neoplasms
Crohn Disease
Neoplasms
Ileitis
Colitis
Ulcerative Colitis
Age of Onset
Rectum
Japan
Pathologic Constriction
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kamiya, T., Ando, T., Ishiguro, K., Maeda, O., Watanabe, O., Hibi, S., ... Goto, H. (2012). Intestinal cancers occurring in patients with Crohn's disease. Journal of Gastroenterology and Hepatology (Australia), 27(SUPPL.3), 103-107. https://doi.org/10.1111/j.1440-1746.2012.07082.x
Kamiya, Toru ; Ando, Takafumi ; Ishiguro, Kazuhiro ; Maeda, Osamu ; Watanabe, Osamu ; Hibi, Satoshi ; Mimura, Shunya ; Ujihara, Masaki ; Hirayama, Yutaka ; Nakamura, Masanao ; Miyahara, Ryoji ; Ohmiya, Naoki ; Goto, Hidemi. / Intestinal cancers occurring in patients with Crohn's disease. In: Journal of Gastroenterology and Hepatology (Australia). 2012 ; Vol. 27, No. SUPPL.3. pp. 103-107.
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Kamiya, T, Ando, T, Ishiguro, K, Maeda, O, Watanabe, O, Hibi, S, Mimura, S, Ujihara, M, Hirayama, Y, Nakamura, M, Miyahara, R, Ohmiya, N & Goto, H 2012, 'Intestinal cancers occurring in patients with Crohn's disease', Journal of Gastroenterology and Hepatology (Australia), vol. 27, no. SUPPL.3, pp. 103-107. https://doi.org/10.1111/j.1440-1746.2012.07082.x

Intestinal cancers occurring in patients with Crohn's disease. / Kamiya, Toru; Ando, Takafumi; Ishiguro, Kazuhiro; Maeda, Osamu; Watanabe, Osamu; Hibi, Satoshi; Mimura, Shunya; Ujihara, Masaki; Hirayama, Yutaka; Nakamura, Masanao; Miyahara, Ryoji; Ohmiya, Naoki; Goto, Hidemi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 27, No. SUPPL.3, 01.01.2012, p. 103-107.

Research output: Contribution to journalArticle

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T1 - Intestinal cancers occurring in patients with Crohn's disease

AU - Kamiya, Toru

AU - Ando, Takafumi

AU - Ishiguro, Kazuhiro

AU - Maeda, Osamu

AU - Watanabe, Osamu

AU - Hibi, Satoshi

AU - Mimura, Shunya

AU - Ujihara, Masaki

AU - Hirayama, Yutaka

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Ohmiya, Naoki

AU - Goto, Hidemi

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background and Aims: The number of patients with Crohn's disease (CD) and the number of cases of intestinal cancer associated with CD have both been increasing in Japan. However, the number of reported cases is lower than for ulcerative colitis-associated cancer. The aim of this study was to identify the clinical picture of CD-associated intestinal cancer in a consecutive series of patients with CD and to stress the importance of surveillance. Methods: We enrolled 174 consecutive patients (130 men, 44 women, mean age 25years) diagnosed with CD and investigated the development of intestinal cancer from October 1998 to July 2010. There were 104 cases of the ileocolitis type, 47 of ileitis, and 23 of colitis. Results: Intestinal cancer developed in two male patients (1.5% of the total), whose respective ages at onset of CD were 41 and 19years, and 55 and 37years at onset of cancer. Both cases were of ileocolitis-type CD; one cancer developed in the rectum and the other in the small bowel, and both were accompanied by severe stricture. Histopathological results revealed well and moderately differentiated adenocarcinoma, respectively. Conclusions: Intestinal cancer developed in patients with ileocolitis-type CD of more than 10years' duration. Our findings suggest that patients with chronic, widespread CD should be under cancer surveillance.

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